Accurate control of gene expression is essential for normal development and dysregulation
of transcription underpins cancer onset and progression. Similar to cell cycle regulation …

The smallest viable unit of life is the cell. From bacteria to mammals, all cells use the same
nucleic acid-based universal code for the maintenance and inheritance of genetic …

The C-terminal domain (CTD) of the RNA polymerase II largest subunit consists of multiple
heptad repeats (consensus Tyr1–Ser2–Pro3–Thr4–Ser5–Pro6–Ser7), varying in number …

Protein phosphatase 1 (PP1) is a major eukaryotic protein serine/threonine phosphatase
that regulates an enormous variety of cellular functions through the interaction of its catalytic …

The precise mechanistic relationship between gene activation and repression events is a
central question in mammalian organogenesis, as exemplified by the evolutionarily …

Appreciable advances into the process of transcript elongation by RNA polymerase II (RNAP
II) have identified this stage as a dynamic and highly regulated step of the transcription …

The HAD (haloacid dehalogenase) superfamily includes phosphoesterases, ATPases,
phosphonatases, dehalogenases, and sugar phosphomutases acting on a remarkably …

Remodelling of the nuclear membrane is essential for the dynamic changes of nuclear
architecture at different stages of the cell cycle and during cell differentiation. The molecular …

The C-terminal domain (CTD) of the RNA polymerase II (Pol II) largest subunit is
hyperphosphorylated during transcription. Using an in vivo cross-linking/chromatin …

The histone methyltransferase Set2, which specifically methylates lysine 36 of histone H3,
has been shown to repress transcription upon tethering to a heterologous promoter …