The introduction of nuclear magnetic resonance (NMR) spectroscopy as a second method
for protein structure determination at atomic resolution, in addition to x-ray diffraction in …

The applications of disulfide-bond chemistry to studies of protein folding, structure, and
stability are reviewed and illustrated with bovine pancreatic ribonuclease A (RNase A). After …

In order to obtain a novel binding protein against a chosen target, DNA molecules, each
encoding a protein comprising one of a family of similar potential binding domains and a …

The envelope glycoprotein of human immunodeficiency virus type 1 (HIV-1) consists of a
complex of gp120 and gp41. gp120 determines viral tropism by binding to target-cell …

In order to obtain a novel binding protein against a chosen target, DNA molecules, each
encoding a protein comprising one of a family of similar potential binding domains and a …

SEVERAL model systems have been used to evaluate the α-helical propensities of different
amino acids1–7. In contrast, experimental quantitation of β-sheet preferences has been …

In this review, we shall outline the basic principles Ž. of circular dichroism CD and indicate
the types of structural information relevant to the study of the Ž. folding and unfolding or …

The diffusion‐collision model of protein folding is assessed. A description is given of the
qualitative aspects and quantitative results of the diffusion‐collision model and their relation …

Activating mutations of~ 53 promote tumor progression. The mutant protein adopts a
characteristic conformation, which lacks the growth suppressor function of wild-type~ 53. We …

1. THE PROTEIN FOLDING PROBLEM To be biologically active, all proteins must adopt
specific folded three-dimensional structures. Yet the genetic information for the protein …