Parturition at term in normal pregnancy follows a predictable sequence of events. There is
some evidence that a state of inflammation prevails in the reproductive tissues during labor …

Epidemiological data convey severe prognosis and high mortality rate for COVID-19 in
elderly men affected by age-related diseases. These subjects develop local and systemic …

Current literature agrees on the notion that efficient DNA repair favors longevity across
evolution. The DNA damage response machinery activates inflammation and type I …

The accumulation of nucleic acids in aberrant compartments is a signal of danger: fragments
of cytosolic or extracellular self-DNA indicate cellular dysfunctions or disruption, whereas …

Circulating cell-free DNA (cfDNA) has become a potential diagnostic and prognostic
biomarker for colorectal cancer (CRC). In non-cancerous diseases, it has been confirmed …

Inflamm-aging depicts the progressive activation of the innate immune system that
accompanies human aging. Its role as a disease-predisposing condition has been …

Cell-free fetal DNA in the maternal circulation has been associated with the onset of labor at
term. Moreover, clinical studies have suggested that cell-free fetal DNA has value to predict …

Problem Pregnancy represents a state of systemic immune activation that is primarily driven
by alterations in circulating innate immune cells. Recent studies have suggested that cellular …

Pregnancy is a tightly regulated immunological state. Mild environmental perturbations can
affect the developing fetus significantly. Infections can elicit severe immunological cascades …

Danger-associated molecular patterns (DAMPs) are elevated within the amniotic cavity, and
their increases correlate with advancing gestational age, chorioamnionitis, and labor …