Clinical investigations using stem cell products in regenerative medicine are addressing a
wide spectrum of conditions using a variety of stem cell types. To date, there have been few …

Endothelial progenitor cells (EPCs) are currently being studied as candidate cell sources for
revascularization strategies. Significant advances have been made in understanding the …

After the onset of ischemia, cardiac or skeletal muscle undergoes a continuum of molecular,
cellular, and extracellular responses that determine the function and the remodeling of the …

CD34 is a cell surface antigen expressed in numerous stem/progenitor cells including
hematopoietic stem cells (HSCs) and endothelial progenitor cells (EPCs), which are known …

Although cellular therapies represent a promising strategy for a number of conditions,
current approaches face major translational hurdles, including limited cell sources and the …

Diabetic foot ulcer (DFU) is one of the most severe complications of diabetes mellitus, often
resulting in a limb amputation. A cell-based therapy is a highly promising approach for an …

Objective/Background Critical limb ischemia (CLI) is the most advanced stage of peripheral
artery disease (PAD), and many patients with CLI are not eligible for conventional …

Critical limb ischemia (CLI) constitutes the most severe form of peripheral arterial disease
(PAD), it is characterized by progressive blockade of arterial vessels, commonly correlated …

Highlights•The goal of angiogenesis in PAD is formation of collateral circulation.•It may be
particularly useful for patients no deemed candidates for revascularization.•Angiogenic …

Since the discovery of Endothelial Progenitor Cells (EPC) by Asahara and colleagues in
1997, an increasing number of preclinical studies have shown that EPC based therapy is …