Repeated, episodic bouts of skeletal muscle contraction undertaken frequently as structured
exercise training are a potent stimulus for physiological adaptation in many organs …

Mechanisms underlying mechanical overload-induced skeletal muscle hypertrophy have
been extensively researched since the landmark report by Morpurgo (1897) of “work …

Human skeletal muscle demonstrates remarkable plasticity, adapting to numerous external
stimuli including the habitual level of contractile loading. Accordingly, muscle function and …

Skeletal muscle plasticity enables an enormous potential to adapt to various internal and
external stimuli and perturbations. Most notably, changes in contractile activity evoke a …

The mechanisms leading to a predominantly hypertrophied phenotype versus a
predominantly oxidative phenotype, the hallmarks of resistance training (RT) or aerobic …

The development of sarcopenia in the elderly is associated with many potential factors
and/or processes that impair the renovation and maintenance of skeletal muscle mass and …

A detailed understanding of molecular responses to a hypertrophic stimulus in skeletal
muscle leads to therapeutic advances aimed at promoting muscle mass. To decode the …

The ability of skeletal muscle to adapt to repeated contractile stimuli is one of the most
intriguing aspects of physiology. The molecular bases underpinning these adaptations …

New Findings What is the topic of this review? Blood‐flow‐restricted (BFR) exercise
represents a potential approach to augment the adaptive response to training and improve …

Old skeletal muscle exhibits decreased anabolic sensitivity, eventually contributing to
muscle wasting. Besides anabolism, also muscle inflammation and catabolism are critical …