Vascular endothelial growth factor receptor (VEGFR)-1 exists in different forms, derived from
alternative splicing of the same gene. In addition to the transmembrane form, endothelial …

Vascular endothelial growth factors (VEGF), Vascular endothelial growth factor receptors
(VEGFR) and their downstream signaling pathways are promising targets in anti-angiogenic …

Interfering with interactions of vascular endothelial growth factors (VEGFs) with their
receptors (VEGFRs) effectively inhibits angiogenesis and tumor growth. We designed an …

Macromolecular ligands targeting vascular endothelial growth factor A (VEGF) to inhibit
pathological angiogenesis are used in the clinic for the treatment of cancers and ocular …

Vascular endothelial growth factor receptor 2 (VEGFR2) mediates VEGFA signaling mainly
through the PI3K/AKT/mTOR and PLCγ/ERK1/2 pathways. Here we unveil a peptidomimetic …

Vascular endothelial growth factors (VEGFs) and their receptors (VEGFRs) are pivotal
regulators of angiogenesis. The VEGF–VEGFR system is therefore an important target of …

Tumor angiogenesis is regulated by the binding of VEGF to receptors (VEGFRs). The major
mediator of tumor angiogenesis is VEGFA, more commonly referred to as VEGF. VEGFR1 …

Bearing in mind the doctrine of tumor angiogenesis hypothesized by Folkman several
decades ago, the fundamental strategy for alleviating numerous cancer indications may be …

Vascular endothelial growth factor B (VEGFB) is a pleiotropic trophic factor, which in contrast
to the closely related VEGFA is known to have a limited effect on angiogenesis. VEGFB …

Pigment epithelium-derived factor (PEDF) is a member of the serine proteinase inhibitor
(serpin) with antiangiogenic, anti-tumorigenic, antioxidant, anti-atherosclerosis …