ABSTRACT DNA methylation is an epigenetic modification critical to normal genome
regulation and development. The vitamin folate is a key source of the one carbon group …

Changes in human DNA methylation patterns are an important feature of cancer
development and progression and a potential role in other conditions such as …

Loss of the de novo DNA methyltransferases Dnmt3a and Dnmt3b in embryonic stem cells
obstructs differentiation; however, the role of these enzymes in somatic stem cells is largely …

Immune cells in the tumor microenvironment have an important role in regulating tumor
progression. Therefore, stimulating immune reactions to tumors can be an attractive …

A growing body of evidence points towards epigenetic mechanisms being responsible for a
wide range of biological phenomena, from the plasticity of plant growth and development to …

Genome-wide DNA hypomethylation plays has an important role in genomic instability and
colorectal carcinogenesis. However, the relationship between cellular DNA methylation …

DNA hypomethylation is a common trait of colorectal cancer. Studies in tumor cell lines and
animal models indicate that genome-wide demethylation may cause genetic instability and …

We report a new mechanism in carcinogenesis involving coordinate long-range epigenetic
gene silencing. Epigenetic silencing in cancer has always been envisaged as a local event …

We studied the relationships between genetic and epigenetic alterations in gastrointestinal
cancer by integrating DNA copy number changes determined by arbitrarily primed PCR (AP …

Background Alterations in DNA methylation in cancer include global hypomethylation and
gene-specific hypermethylation. It is not clear whether these two epigenetic errors are …