The application of omics-based human liver platforms for investigating the mechanism of drug-induced hepatotoxicity in vitro

J Jiang, CD Pieterman, G Ertaylan, RLM Peeters… - Archives of …, 2019 - Springer
Drug-induced liver injury (DILI) complicates safety assessment for new drugs and poses
major threats to both patient health and drug development in the pharmaceutical industry. A …

Mining a human transcriptome database for chemical modulators of NRF2

JP Rooney, B Chorley, S Hiemstra, S Wink, X Wang… - PloS one, 2020 - journals.plos.org
Nuclear factor erythroid-2 related factor 2 (NRF2) encoded by the NFE2L2 gene is a
transcription factor critical for protecting cells from chemically-induced oxidative stress. We …

Differential epigenetic effects of atmospheric cold plasma on MCF-7 and MDA-MB-231 breast cancer cells

SB Park, B Kim, H Bae, H Lee, S Lee, EH Choi, SJ Kim - PloS one, 2015 - journals.plos.org
Cold atmospheric plasma (plasma) has emerged as a novel tool for a cancer treatment
option, having been successfully applied to a few types of cancer cells, as well as tissues …

Oxidative stress-induced inflammatory responses and effects of N-acetylcysteine in bovine mammary alveolar cells

H Bae, CH Jeong, WN Cheng, K Hong… - Journal of Dairy …, 2017 - cambridge.org
Bovine mastitis, an inflammation of the udder, results in reduced milk production and poor
milk quality. Mastitis is usually, but not always, a response to pathogen infection. High milk …

Disruption of mitochondrial function as mechanism for anti-cancer activity of a novel mitochondriotropic menadione derivative

J Teixeira, R Amorim, K Santos, P Soares, S Datta… - Toxicology, 2018 - Elsevier
Menadione, also known as vitamin K 3, is a 2-methyl-1, 4 naphthoquinone with a potent
cytotoxic activity mainly resulting from its quinone redox-cycling with production of reactive …

[HTML][HTML] Superoxide-hydrogen peroxide imbalance interferes with colorectal cancer cells viability, proliferation and oxaliplatin response

VF Azzolin, FC Cadoná, AK Machado, M Dal Berto… - Toxicology in Vitro, 2016 - Elsevier
The role of superoxide dismutase manganese dependent enzyme (SOD2) in colorectal
cancer is presently insufficiently understood. Some studies suggest that high SOD2 levels …

Comparison of Anticancer Activity of Dorycnium pentaphyllum Extract on MCF-7 and MCF-12A Cell Line: Correlation with Invasion and Adhesion

G Koygun, E Arslan, G Zengin, G Orlando, C Ferrante - Biomolecules, 2021 - mdpi.com
Dorycnium pentaphyllum subsp. haussknechtii is an important medicinal plant in several
countries, including Turkey. This study aimed to evaluate the cytotoxicity of a crude extract of …

[HTML][HTML] Роль окислительного стресса и антиоксидантной защиты в репродукции человека

ИВ Кузнецова - Акушерство и гинекология, 2016 - medi.ru
Objective. To carry out a systematic analysis of the data available in the literature on the
impact of oxidative stress on fertility of both sexes. Subject and methods. For analysis …

Progression of Hepatic Adenoma to Carcinoma in Ogg1 Mutant Mice Induced by Phenobarbital

A Kakehashi, N Ishii, T Okuno, M Fujioka… - Oxidative Medicine …, 2017 - Wiley Online Library
The carcinogenic potential of phenobarbital (PB) was assessed in a mouse line carrying a
mutant Mmh allele of the Mmh/Ogg1 gene encoding the enzyme oxoguanine DNA …

Role of oxidative stress and antioxidant defense in human reproduction

IV Kuznetsova - Obstetrics and gynecology, 2016 - cardiosomatics.orscience.ru
Objective. To carry out a systematic analysis of the data available in the literature on the
impact of oxidative stress on fertility of both sexes. Subject and methods. For analysis …