The recommendations listed in this clinical practice guideline are, whenever possible,
evidence-based. An initial extensive evidence review, which included literature derived from …

There has been a significant progress in our understanding of the molecular mechanisms by
which calcium (Ca2+) ions mediate various types of cardiac arrhythmias. A growing list of …

Arrhythmogenic cardiomyopathy (ACM) is an arrhythmogenic disorder of the myocardium
not secondary to ischemic, hypertensive, or valvular heart disease. ACM incorporates a …

Myocardial diseases are associated with an increased risk of potentially fatal cardiac
arrhythmias and sudden cardiac death/cardiac arrest during exercise, including hypertrophic …

Arrhythmogenic cardiomyopathy is an inherited heart muscle disorder, predisposing to
sudden cardiac death, particularly in young patients and athletes. Pathological features …

Arrhythmogenic right ventricular cardiomyopathy/dysplasia (ARVC/D) is an inherited
cardiomyopathy that can lead to sudden cardiac death and heart failure. Our understanding …

Arrhythmogenic right ventricular cardiomyopathy is a heritable heart-muscle disorder that
causes progressive replacement of right ventricular myocardium by fibrofatty tissue …

Criteria for diagnosis of arrhythmogenic cardiomyopathy (ACM) were first proposed in 1994
and revised in 2010 by a Task Force. Although the Task Force criteria demonstrated a good …

1From Mayo Clinic, Rochester, Minnesota; 2Fondazione Salvatore Maugeri University of
Pavia, Pavia, Italy and New York University, New York, New York; 3University Hospital …

To assess factors influencing the success of whole-genome sequencing for mainstream
clinical diagnosis, we sequenced 217 individuals from 156 independent cases or families …