Hypothalamic–pituitary–adrenal and hypothalamic–pituitary–gonadal axes: sex differences in regulation of stress responsivity

MG Oyola, RJ Handa - stress, 2017 - Taylor & Francis
Gonadal hormones play a key role in the establishment, activation, and regulation of the
hypothalamic–pituitary–adrenal (HPA) axis. By influencing the response and sensitivity to …

Sex differences in the hypothalamic–pituitary–adrenal axis' response to stress: an important role for gonadal hormones

AL Heck, RJ Handa - Neuropsychopharmacology, 2019 - nature.com
The hypothalamic–pituitary–adrenal (HPA) axis, a neuroendocrine network that controls
hormonal responses to internal and external challenges in an organism's environment …

Overshadowed by the amygdala: the bed nucleus of the stria terminalis emerges as key to psychiatric disorders

MA Lebow, A Chen - Molecular psychiatry, 2016 - nature.com
The bed nucleus of the stria terminalis (BNST) is a center of integration for limbic information
and valence monitoring. The BNST, sometimes referred to as the extended amygdala, is …

Mechanisms for estrogen receptor expression in human cancer

H Hua, H Zhang, Q Kong, Y Jiang - Experimental hematology & oncology, 2018 - Springer
Estrogen is a steroid hormone that has critical roles in reproductive development, bone
homeostasis, cardiovascular remodeling and brain functions. However, estrogen also …

Sex differences in anxiety and depression: role of testosterone

J McHenry, N Carrier, E Hull, M Kabbaj - Frontiers in neuroendocrinology, 2014 - Elsevier
Compelling evidence exists for pervasive sex differences in pathological conditions,
including anxiety and depressive disorders, with females more than twice as likely to be …

[PDF][PDF] Sex differences in the HPA axis

N Goel, JL Workman, TT Lee, L Innala, V Viau - Compr Physiol, 2014 - academia.edu
The hypothalamic-pituitary-adrenal (HPA) axis is a major component of the systems that
respond to stress, by coordinating the neuroendocrine and autonomic responses. Tightly …

Evolution of a vertebrate social decision-making network

LA O'Connell, HA Hofmann - Science, 2012 - science.org
Animals evaluate and respond to their social environment with adaptive decisions.
Revealing the neural mechanisms of such decisions is a major goal in biology. We analyzed …

[HTML][HTML] Prolactin: structure, function, and regulation of secretion

ME Freeman, B Kanyicska, A Lerant… - Physiological …, 2000 - journals.physiology.org
Prolactin is a protein hormone of the anterior pituitary gland that was originally named for its
ability to promote lactation in response to the suckling stimulus of hungry young mammals …

Gonadal steroid hormones and the hypothalamo–pituitary–adrenal axis

RJ Handa, MJ Weiser - Frontiers in neuroendocrinology, 2014 - Elsevier
The hypothalamo–pituitary–adrenal (HPA) axis represents a complex neuroendocrine
feedback loop controlling the secretion of adrenal glucocorticoid hormones. Central to its …

Estrogen receptors: how do they signal and what are their targets

N Heldring, A Pike, S Andersson… - Physiological …, 2007 - journals.physiology.org
During the past decade there has been a substantial advance in our understanding of
estrogen signaling both from a clinical as well as a preclinical perspective. Estrogen …