The ability to replace organs and tissues on demand could save or improve millions of lives
each year globally and create public health benefits on par with curing cancer. Unmet needs …

In this concept article, we outline a variety of new approaches that have been conceived to
address some of the remaining challenges for developing improved methods of …

Background The requirement for heart transplantation is increasing, vastly outgrowing the
supply of hearts available from donation after brain death (DBD) donors. Transplanting …

Summary Background The Organ Care System is the only clinical platform for ex-vivo
perfusion of human donor hearts. The system preserves the donor heart in a warm beating …

Background Orthotopic heart transplantation is the gold-standard long-term treatment for
medically refractive end-stage heart failure. However, suitable cardiac donors are scarce …

Pre-clinical heart transplantation studies have shown that ex vivo non-ischemic heart
preservation (NIHP) can be safely used for 24 h. Here we perform a prospective, open-label …

Despite advances in pharmacologic and device treatment of chronic heart failure, long-term
morbidity and mortality remain high, and many patients progress to end-stage heart failure …

Heart transplantation from donation after circulatory death (DCD) donors has the potential to
substantially increase overall heart transplant activity. The aim of this report is to review the …

Background A significant proportion of kidneys procured for transplantation are discarded
because of concerns about their suitability. In this study ex vivo normothermic perfusion …

The three classical core technologies for the preservation of live mammalian biospecimens—
slow freezing, vitrification and hypothermic storage—limit the biomedical applications of …