Most solid tumor cells adapt to their heterogeneous microenvironment by depending largely
on aerobic glycolysis for energy production, a phenomenon called the Warburg effect, which …

Angiogenesis is a hallmark of cancer and is required for tumor growth and progression.
Antiangiogenic therapy has been revolutionarily developing and was approved for the …

Glucose uptake is essential for cancer glycolysis and is involved in non-shivering
thermogenesis of adipose tissues,,,,–. Most cancers use glycolysis to harness energy for …

Deregulation of angiogenesis–the growth of new blood vessels from an existing vasculature–
is a main driving force in many severe human diseases including cancer. As such, tumor …

Vascular pericytes, an important cellular component in the tumor microenvironment, are
often associated with tumor vasculatures, and their functions in cancer invasion and …

Organ-specific metastasis is the primary cause of cancer patient death. The distant
metastasis of tumor cells to specific organs depends on both the intrinsic characteristics of …

Fibrosis is part of a tissue repair response to injury, defined as increased deposition of
extracellular matrix. In some instances, fibrosis is beneficial; however, in the majority of …

Anoikis is a type of programmed cell death induced by loss of anchorage to the extracellular
matrix (ECM). Anoikis resistance (AR) is crucial for the survival of metastatic cancer cells in …

Platelet‐derived growth factor (PDGF) isoforms and their receptors have important roles
during embryogenesis, particularly in the development of various mesenchymal cell types in …

FGF-2 displays multifarious functions in regulation of angiogenesis and vascular
remodeling. However, effective drugs for treating FGF-2+ tumors are unavailable. Here we …