The bone marrow niche has mystified scientists for many years, leading to widespread
investigation to shed light into its molecular and cellular composition. Considerable efforts …

All hematopoietic and immune cells are continuously generated by hematopoietic stem cells
(HSCs) and hematopoietic progenitor cells (HPCs) through highly organized process of …

Arterioles and sinusoids of the bone marrow (BM) are accompanied by stromal cells that
express nerve/glial antigen 2 (NG2) and leptin receptor (LepR), and constitute specialized …

The intermediate filament protein Nestin labels populations of stem/progenitor cells,
including self-renewing mesenchymal stem cells (MSCs), a major constituent of the …

Chemokines have crucial roles in organ development and orchestration of leukocyte
migration. The chemokine CCL22 is expressed constitutively at high levels in the lymph …

Significance: Blood forming, hematopoietic stem cells (HSCs) mostly reside in the bone
marrow in a quiescent, nonmotile state via adhesion interactions with stromal cells and …

In the central nervous system (CNS), astrocytes form networks interconnected by gap
junctions made from connexins of the subtypes Cx30 and Cx43. When unopposed by an …

Accumulating evidence suggests that spinal cord astrocytes play an important role in
neuropathic pain sensitization by releasing astrocytic mediators (eg cytokines, chemokines …

Although the function of the autonomic nervous system (ANS) in mediating the flight-or-fight
response was recognized decades ago, the crucial role of peripheral innervation in …

Adult haematopoietic stem cells (HSCs) mainly reside in the bone marrow, where stromal
and haematopoietic cells regulate their function. The steady state HSC niche has been …