Quantitative analysis of drug-receptor interactions: I. Determination of kinetic and equilibrium properties

GA Weiland, PB Molinoff - Life sciences, 1981 - Elsevier
It has recently become possible to characterize a variety of different receptors by studying
the binding of appropriate drugs labelled with 3 H or 125 I. The goal of this review is to …

Fluorescence microphotolysis to measure nucleocytoplasmic transport and intracellular mobility

R Peters - Biochimica et Biophysica Acta (BBA)-Reviews on …, 1986 - Elsevier
Nucleocytoplasmic transport and intracellular mobility belong to the primary characteristics
of the eukaryotic cell. Since genetic material and the protein synthesizing apparatus are …

[HTML][HTML] A ternary complex model explains the agonist-specific binding properties of the adenylate cyclase-coupled beta-adrenergic receptor.

A De Lean, JM Stadel, RJ Lefkowitz - Journal of Biological Chemistry, 1980 - Elsevier
The unique properties of agonist binding to the frog erythrocyte beta-adrenergic receptor
include the existence of two affinity forms of the receptor. The proportion and relative affinity …

Taxol binds to polymerized tubulin in vitro

J Parness, SB Horwitz - The Journal of cell biology, 1981 - rupress.org
Taxol, a natural plant product that enhances the rate and extent of microtubule assembly in
vitro and stabilizes microtubules in vitro and in cells, was labeled with tritium by catalytic …

[PDF][PDF] A quantitative analysis of beta-adrenergic receptor interactions: resolution of high and low affinity states of the receptor by computer modeling of ligand binding …

RS KENT, A De Lean, RJ LEFKOWITZ - Molecular Pharmacology, 1980 - Citeseer
SUMMARY KENT, RS, A. DE LEAN AND RJ LEFKOWITZ. A quantitative analysis of beta-
adrenergic receptor interactions: Resolution of high and low affinity states of the receptor by …

Mode of coupling between the β-adrenergic receptor and adenylate cyclase in turkey erythrocytes

AM Tolkovsky, A Levitzki - Biochemistry, 1978 - ACS Publications
Aviva M. Tolkovsky and Alexander Levitzki* abstract: The mode of coupling of the/3-
adrenergic receptor to the enzyme adenylate cyclase in turkey erythrocyte mem-branes was …

[HTML][HTML] Site-site interactions among insulin receptors. Characterization of the negative cooperativity.

P DeMeyts, AR Bainco, J Roth - Journal of Biological Chemistry, 1976 - Elsevier
By studying the dissociation of 125I-instulin from its receptors in the absence and phe
negatively cooperative type for the insulin receptors. In the present study we extend oy …

[HTML][HTML] Anterior pituitary dopamine receptors. Demonstration of interconvertible high and low affinity states of the D-2 dopamine receptor.

DR Sibley, A De Lean, I Creese - Journal of Biological Chemistry, 1982 - Elsevier
The interactions of dopaminergic agonists and antagonists with binding sites in bovine
anterior pituitary membranes have been investigated with radioligand-binding techniques …

[HTML][HTML] Lipoxin recognition sites. Specific binding of labeled lipoxin A4 with human neutrophils.

S Fiore, SW Ryeom, PF Weller, CN Serhan - Journal of Biological …, 1992 - Elsevier
Lipoxin A4 stimulates rapid lipid remodeling and a pertussis toxin-sensitive release of
arachidonic acid in polymorphonuclear leukocytes (PMN)(Nigam, S., Fiore, S., Luscinskas …

Interaction of cholecystokinin with specific membrane receptors on pancreatic acinar cells

RT Jensen, GF Lemp… - Proceedings of the …, 1980 - National Acad Sciences
We have prepared 125I-labeled cholecystokinin and have examined the kinetics,
stoichiometry, and chemical specificity with which the labeled peptide binds to dispersed …