Improved model systems to predict drug efficacy, interactions, and drug-induced kidney
injury (DIKI) are crucially needed in drug development. Organ-on-a-chip technology is a …

Microfluidic lumen-based systems are microscale models that recapitulate the anatomy and
physiology of tubular organs. These technologies can mimic human pathophysiology and …

Drug-transporter interactions could impact renal drug clearance and should ideally be
detected in early stages of drug development to avoid toxicity-related withdrawals in later …

Renal disease represents a major health problem that often results in end-stage renal failure
necessitating dialysis and eventually transplantation. Historically these diseases have been …

The emergence of immunotherapies and recent FDA approval of several of them makes
them a promising therapeutic strategy for cancer. While these advancements underscore the …

Membrane technology is playing a crucial role in cutting-edge innovations in the biomedical
field. One such innovation is the surface engineering of a membrane for enhanced longevity …

The extracellular matrix (ECM), a complex set of fibrillar proteins and proteoglycans,
supports the renal parenchyma and provides biomechanical and biochemical cues critical …

The prevalence of end-stage renal disease is emerging as a serious worldwide public
health problem because of the shortage of donor organs and the need to take lifelong …

In vitro models that can faithfully replicate critical aspects of kidney tubule function such as
directional drug transport are in high demand in pharmacology and toxicology. Accordingly …

Miniaturization in the fields of chemistry and molecular biology has resulted in the" lab-on-a-
chip." Such systems are micro-fabricated devices capable of handling extremely small fluid …