Ebola virus disease
ST Jacob, I Crozier, WA Fischer, A Hewlett… - Nature reviews Disease …, 2020 - nature.com
Ebola virus disease (EVD) is a severe and frequently lethal disease caused by Ebola virus
(EBOV). EVD outbreaks typically start from a single case of probable zoonotic transmission …
(EBOV). EVD outbreaks typically start from a single case of probable zoonotic transmission …
Ebola haemorrhagic fever
H Feldmann, TW Geisbert - The Lancet, 2011 - thelancet.com
Ebola viruses are the causative agents of a severe form of viral haemorrhagic fever in man,
designated Ebola haemorrhagic fever, and are endemic in regions of central Africa. The …
designated Ebola haemorrhagic fever, and are endemic in regions of central Africa. The …
Implications of antibody-dependent enhancement of infection for SARS-CoV-2 countermeasures
N Eroshenko, T Gill, MK Keaveney, GM Church… - Nature …, 2020 - nature.com
To the Editor—For certain diseases, patients who have been previously infected by one
strain of a virus and who are later infected by another strain can suffer outcomes that are …
strain of a virus and who are later infected by another strain can suffer outcomes that are …
Pathogenicity and virulence of Marburg virus
Marburg virus (MARV) has been a major concern since 1967, with two major outbreaks
occurring in 1998 and 2004. Infection from MARV results in severe hemorrhagic fever …
occurring in 1998 and 2004. Infection from MARV results in severe hemorrhagic fever …
Filovirus pathogenesis and immune evasion: insights from Ebola virus and Marburg virus
I Messaoudi, GK Amarasinghe, CF Basler - Nature Reviews …, 2015 - nature.com
Ebola viruses and Marburg viruses, members of the filovirus family, are zoonotic pathogens
that cause severe disease in people, as highlighted by the latest Ebola virus epidemic in …
that cause severe disease in people, as highlighted by the latest Ebola virus epidemic in …
Human Ebola virus infection results in substantial immune activation
AK McElroy, RS Akondy, CW Davis… - Proceedings of the …, 2015 - National Acad Sciences
Four Ebola patients received care at Emory University Hospital, presenting a unique
opportunity to examine the cellular immune responses during acute Ebola virus infection …
opportunity to examine the cellular immune responses during acute Ebola virus infection …
Lymphopenia caused by virus infections and the mechanisms beyond
Z Guo, Z Zhang, M Prajapati, Y Li - Viruses, 2021 - mdpi.com
Viral infections can give rise to a systemic decrease in the total number of lymphocytes in the
blood, referred to as lymphopenia. Lymphopenia may affect the host adaptive immune …
blood, referred to as lymphopenia. Lymphopenia may affect the host adaptive immune …
Human fatal zaire ebola virus infection is associated with an aberrant innate immunity and with massive lymphocyte apoptosis
N Wauquier, P Becquart, C Padilla… - PLoS neglected …, 2010 - journals.plos.org
Background Ebolavirus species Zaire (ZEBOV) causes highly lethal hemorrhagic fever,
resulting in the death of 90% of patients within days. Most information on immune responses …
resulting in the death of 90% of patients within days. Most information on immune responses …
Ebola virus VP24 binds karyopherin α1 and blocks STAT1 nuclear accumulation
SP Reid, LW Leung, AL Hartman, O Martinez… - Journal of …, 2006 - Am Soc Microbiol
Ebola virus (EBOV) infection blocks cellular production of alpha/beta interferon (IFN-α/β) and
the ability of cells to respond to IFN-α/β or IFN-γ. The EBOV VP35 protein has previously …
the ability of cells to respond to IFN-α/β or IFN-γ. The EBOV VP35 protein has previously …
Ebola virus VP35 protein binds double-stranded RNA and inhibits alpha/beta interferon production induced by RIG-I signaling
ABSTRACT The Ebola virus (EBOV) VP35 protein blocks the virus-induced phosphorylation
and activation of interferon regulatory factor 3 (IRF-3), a transcription factor critical for the …
and activation of interferon regulatory factor 3 (IRF-3), a transcription factor critical for the …