Interactions between nanoparticles and dendritic cells: from the perspective of cancer immunotherapy
Dendritic cells (DCs) are the primary antigen-presenting cells and play key roles in the
orchestration of the innate and adaptive immune system. Targeting DCs by nanotechnology …
orchestration of the innate and adaptive immune system. Targeting DCs by nanotechnology …
Adverse outcome pathways as a tool for the design of testing strategies to support the safety assessment of emerging advanced materials at the nanoscale
S Halappanavar, S Van Den Brule, P Nymark… - Particle and Fibre …, 2020 - Springer
Toxicity testing and regulation of advanced materials at the nanoscale, ie nanosafety, is
challenged by the growing number of nanomaterials and their property variants requiring …
challenged by the growing number of nanomaterials and their property variants requiring …
Citrullinated vimentin mediates development and progression of lung fibrosis
The mechanisms by which environmental exposures contribute to the pathogenesis of lung
fibrosis are unclear. Here, we demonstrate an increase in cadmium (Cd) and carbon black …
fibrosis are unclear. Here, we demonstrate an increase in cadmium (Cd) and carbon black …
Chronic exposure to carbon black ultrafine particles reprograms macrophage metabolism and accelerates lung cancer
Chronic exposure to airborne carbon black ultrafine (nCB) particles generated from
incomplete combustion of organic matter drives IL-17A–dependent emphysema. However …
incomplete combustion of organic matter drives IL-17A–dependent emphysema. However …
Validating metal‐organic framework nanoparticles for their nanosafety in diverse biomedical applications
Metal‐organic frameworks (MOFs) are promising platforms for the synthesis of nanoparticles
for diverse medical applications. Their fundamental design principles allow for significant …
for diverse medical applications. Their fundamental design principles allow for significant …
Contribution of adaptive immunity to human COPD and experimental models of emphysema
F Kheradmand, Y Zhang, DB Corry - Physiological Reviews, 2023 - journals.physiology.org
The pathophysiology of chronic obstructive pulmonary disease (COPD) and the undisputed
role of innate immune cells in this condition have dominated the field in the basic research …
role of innate immune cells in this condition have dominated the field in the basic research …
Microglia and amyloid precursor protein coordinate control of transient Candida cerebritis with memory deficits
Y Wu, S Du, JL Johnson, HY Tung, CT Landers… - Nature …, 2019 - nature.com
Bloodborne infections with Candida albicans are an increasingly recognized complication of
modern medicine. Here, we present a mouse model of low-grade candidemia to determine …
modern medicine. Here, we present a mouse model of low-grade candidemia to determine …
Effects of tobacco smoke and electronic cigarette vapor exposure on the oral and gut microbiota in humans: a pilot study
Background The use of electronic cigarettes (ECs) has increased drastically over the past
five years, primarily as an alternative to smoking tobacco cigarettes. However, the adverse …
five years, primarily as an alternative to smoking tobacco cigarettes. However, the adverse …
The microRNA miR-22 inhibits the histone deacetylase HDAC4 to promote TH17 cell–dependent emphysema
Smoking-related emphysema is a chronic inflammatory disease driven by the TH17 subset
of helper T cells through molecular mechanisms that remain obscure. Here we explored the …
of helper T cells through molecular mechanisms that remain obscure. Here we explored the …
Targeting chronic obstructive pulmonary disease phenotypes, endotypes, and biomarkers
S Garudadri, PG Woodruff - Annals of the American Thoracic Society, 2018 - atsjournals.org
Chronic obstructive pulmonary disease (COPD) is now well recognized to be a
phenotypically heterogeneous disease, and this heterogeneity is underpinned by biological …
phenotypically heterogeneous disease, and this heterogeneity is underpinned by biological …