Cancer and neurodegeneration are different classes of diseases that share the involvement
of mitochondria in their pathogenesis. Whereas the high glycolytic rate (the so-called …

Already in the early 1960s, researchers noted the potential of mitochondria to take up large
amounts of Ca2+. However, the physiological role and the molecular identity of the …

Background Epidemiological studies have clarified the potential associations between
regular aspirin use and cancers. However, it remains controversial on whether aspirin use …

The voltage-dependent anion channel (VDAC) is a β-barrel membrane protein located in the
outer mitochondrial membrane (OMM). VDAC has two conductance states: an open anion …

Background Nonalcoholic fatty disease (NAFLD) is the most common liver disease, since it
is strongly associated with obesity and metabolic syndrome pandemics. NAFLD may affect …

The limitations of current chemotherapeutic drugs are still a major issue in cancer treatment.
Thus, targeted multimodal therapeutic approaches need to be strategically developed to …

Background Whether aspirin use can decrease or increase cancer risk remains
controversial. In this study, a meta-analysis of cohort studies and randomized controlled …

Anticancer activity of different phenols is documented, but underlying mechanisms remain
elusive. Recently, we have shown that cannabidiol kills the cells of acute lymphoblastic …

Non-small cell lung cancer (NSCLC) has the highest incidence and mortality in the world.
Aspirin has been reported to promote apoptosis, inhibit proliferation, stemness …

Overcoming refractory epilepsy's resistance to the combination of antiepileptic drugs (AED),
mitigating side effects, and preventing sudden unexpected death in epilepsy are critical …