Aneurysmal subarachnoid hemorrhage (aSAH) is a severe type of acute brain injury with
high mortality and burden of neurological sequelae. General management aims at early …

Brain diseases are a leading cause of disability and death worldwide. Early detection can
lead to earlier intervention and better outcomes for patients. In recent years, optical …

Brain edema is a feared complication to disorders and insults affecting the brain. It can be
fatal if the increase in intracranial pressure is sufficiently large to cause brain herniation …

The water channel aquaporin-4 (AQP4) is crucial for water balance in the mammalian brain.
AQP4 has two main canonical isoforms, M23, which forms supramolecular structures called …

With an increasingly elderly population globally, the impacts of cerebrovascular diseases,
such as stroke and dementia, become increasingly significant. Haemorrhagic transformation …

Objective. Haemorrhagic transformation (HT) is one of the most common complications after
ischaemic stroke, caused by damage to the blood–brain barrier (BBB) that could be the …

The quantitative relationship between arterial blood pressure (ABP) and intracranial
pressure (ICP) waveforms has not been adequately explained. We hypothesized that the …

Microcirculation is a key area of interest within the realms of biology and medicine. As a vital
discipline, microcirculatory biology forms a significant part of established medical fields like …

The cerebral microcirculation is a highly complex interconnected network of vessels that
cover a wide range of length scales and respond over a wide range of time scales. It plays a …

The brain occupies around 2% of human adult bodyweight but accounts for nearly 20% of
metabolism in the body and 14% of blood flow. With an increasingly elderly population …