[HTML][HTML] A review on metal complexes and its anti-cancer activities: Recent updates from in vivo studies

S Adhikari, P Nath, A Das, A Datta, N Baildya… - Biomedicine & …, 2024 - Elsevier
Research into cancer therapeutics has uncovered various potential medications based on
metal-containing scaffolds after the discovery and clinical applications of cisplatin as an anti …

Current status of iridium-based complexes against lung cancer

T Yang, M Zhu, M Jiang, F Yang, Z Zhang - Frontiers in Pharmacology, 2022 - frontiersin.org
Lung cancer is one of the most common malignant tumors, with the highest mortality rate in
the world, and its incidence is second only to breast cancer. It has posed a serious threat to …

Significant increase of anticancer efficacy in vitro and in vivo of liposome entrapped ruthenium (II) polypyridyl complexes

Y Chen, W Li, Y Yang, R Zhong, H Hu, C Huang… - European Journal of …, 2023 - Elsevier
Two polypyridyl ruthenium (II) complexes [Ru (DIP) 2 (BIP)](PF 6) 2 (DIP= 4, 7-diphenyl-1, 10-
phenanthrolie, BIP= 2-(1, 1′-biphenyl-4-yl)-1H-imidazo [4, 5-f][1, 10] phenanthroline, Ru1) …

Anticancer effect evaluation in vitro and in vivo of iridium (III) polypyridyl complexes targeting DNA and mitochondria

H Zhang, L Tian, R Xiao, Y Zhou, Y Zhang, J Hao… - Bioorganic …, 2021 - Elsevier
To investigate the antitumor effect of iridium complexes, three iridium (III) complexes [Ir (ppy)
2 (dcdppz)] PF 6 (ppy= 2-phenylpyridine, dcdppz= 11, 12-dichlorodipyrido [3, 2-a: 2′, 3′-c] …

[HTML][HTML] Efficacy and mechanism of active fractions in fruit of Amomum villosum Lour. for gastric cancer

J Yue, S Zhang, B Zheng, F Raza, Z Luo, X Li… - Journal of …, 2021 - ncbi.nlm.nih.gov
Amomi Fructus is the dried ripe fruit of Amomum villosum Lour.(A. villosum). It is a well-
known traditional Chinese medicine widely used to treat gastrointestinal diseases, while the …

Liposomes encapsulated iridium (III) polypyridyl complexes enhance anticancer activity in vitro and in vivo

L Bai, WD Fei, YY Gu, M He, F Du, WY Zhang… - Journal of inorganic …, 2020 - Elsevier
Three iridium (III) complexes [Ir (ppy) 2 (CPIP)](PF 6)(Ir-1, ppy= 2-phenylpyridine, CPIP= 2-(4-
chlorophenyl)-1H-imidazo [4, 5-f][1, 10] phenanthroline),[Ir (ppy) 2 (DCPIP)](PF 6)(Ir-2 …

DNA binding and evaluation of anticancer activity in vitro and in vivo of iridium (III) polypyridyl complexes

Y Zhang, Y Zhou, H Zhang, L Tian, J Hao… - Journal of Inorganic …, 2021 - Elsevier
In this report, we synthesized three new iridium (III) complexes:[Ir (piq) 2 (apip)] PF 6 (Ir1,
piq= 1-phenylisoquinoline, apip= 2-aminophenyl-1H-imidazo [4, 5-f][1, 10] …

Ni (II), Cu (II) and Zn (II) complexes with the 1-trifluoroethoxyl-2, 9, 10-trimethoxy-7-oxoaporphine ligand simultaneously target microtubules and mitochondria for …

LS Liao, Y Chen, ZY Mo, C Hou, GF Su… - Inorganic Chemistry …, 2021 - pubs.rsc.org
Metal complexes of [NiL2 (NO3) 2](1),[CuL2 (NO3) 2](2) and [ZnL2 (NO3) 2](3) with the 1-
trifluoroethoxyl-2, 9, 10-trimethoxy-7-oxoaporphine (L) ligand were synthesized. We …

Enhanced in vitro cytotoxicity and antitumor activity in vivo of iridium (III) complexes liposomes targeting endoplasmic reticulum and mitochondria

W Li, X Wu, H Liu, C Shi, Y Yuan, L Bai, X Liao… - Journal of Inorganic …, 2022 - Elsevier
In this paper, two new iridium (III) complexes [Ir (ppy) 2 (CBIP)](PF 6)(ppy= 2-phenylpyridine,
CBIP= 2-(4′-chloro-(1, 1′-biphenyl))-1H-imidazo [4, 5-f][1, 10] phenanthroline)(Ir1) and [Ir …

Anticancer effect evaluation of iridium (III) complexes targeting mitochondria and endoplasmic reticulum

Y Wang, Y Li, J Chen, H Liu, Y Zhou, C Huang… - Journal of Inorganic …, 2023 - Elsevier
Abstract Ligand HMSPIP (2-(4-(methylsulfonyl) phenyl)-1H-imidazo [4, 5-f][1, 10]
phenanthroline) and its iridium (III) complexes [Ir (ppy) 2 (HMSPIP)] PF 6 (ppy= 2 …