Mass spectrometry (MS) has become one of the key technologies of structural biology. In this
review, the contributions of chemical cross-linking combined with mass spectrometry (XL …

Over the past decade, cross-linking mass spectrometry (CLMS) has developed into a robust
and flexible tool that provides medium-resolution structural information. CLMS data provide …

We describe pLink 2, a search engine with higher speed and reliability for proteome-scale
identification of cross-linked peptides. With a two-stage open search strategy facilitated by …

Protein-protein interactions are fundamental to the formation of intricate interaction networks
and the assembly of multisubunit protein complexes that represent the functional …

In recent years, chemical crosslinking of protein complexes and the identification of
crosslinked residues by mass spectrometry (XL-MS; sometimes abbreviated as CX-MS) has …

Protein aggregates are the hallmark of stressed and ageing cells, and characterize several
pathophysiological states,. Healthy metazoan cells effectively eliminate intracellular protein …

Nuclear pore complexes (NPCs) are 110-megadalton assemblies that mediate
nucleocytoplasmic transport. NPCs are built from multiple copies of~ 30 different …

Muscle contraction is initiated by the release of calcium (Ca2+) from the sarcoplasmic
reticulum into the cytoplasm of myocytes through ryanodine receptors (RyRs). RyRs are …

The nuclear pore complex (NPC) is a fundamental component of all eukaryotic cells that
facilitates nucleocytoplasmic exchange of macromolecules. It is assembled from multiple …

Mitochondrial ribosomes (mitoribosomes) are extensively modified ribosomes of bacterial
descent specialized for the synthesis and insertion of membrane proteins that are critical for …