Proteolytic activation of the epithelial Sodium Channel (ENaC): Its mechanisms and implications

M Aufy, AM Hussein, T Stojanovic, CR Studenik… - International Journal of …, 2023 - mdpi.com
Epithelial sodium channel (ENaC) are integral to maintaining salt and water homeostasis in
various biological tissues, including the kidney, lung, and colon. They enable the selective …

Enhancement of Radiation Sensitivity by Cathepsin L Suppression in Colon Carcinoma Cells

RF Abdelaziz, AM Hussein, MH Kotob, C Weiss… - International Journal of …, 2023 - mdpi.com
Cancer is one of the main causes of death globally. Radiotherapy/Radiation therapy (RT) is
one of the most common and effective cancer treatments. RT utilizes high-energy radiation …

Advances in nanobubbles for cancer theranostics: Delivery, imaging and therapy

L Na, F Fan - Biochemical Pharmacology, 2024 - Elsevier
Maximizing treatment efficacy and forecasting patient prognosis in cancer necessitates the
strategic use of targeted therapy, coupled with the prompt precise detection of malignant …

Cathepsin B-Activated PET Tracer for In Vivo Tumor Imaging

H Li, B Liang, X Gao, Y Peng, Q Liu, L Qiu… - Molecular …, 2024 - ACS Publications
Cathepsin B, a lysosomal protease, is considered as a crucial biomarker for tumor diagnosis
and treatment as it is overexpressed in numerous cancers. A stimulus-responsive SF …

Age-related lung changes linked to altered lysosomal protease profile, histology, and ultrastructure

M Aufy, M Abd-Elkareem, M Mustafic… - PloS one, 2024 - journals.plos.org
Introduction The aging process is intricately linked to alterations in cellular and tissue
structures, with the respiratory system being particularly susceptible to age-related changes …

Genetic heterogeneity of chicken anemia virus isolated in selected Egyptian provinces as a preliminary investigation

S Abdel-Mawgod, A Zanaty, M Elhusseiny… - Frontiers in Veterinary …, 2024 - frontiersin.org
Chicken anemia virus (CAV) is a widespread and economically significant pathogen in the
poultry industry. In this study 110 samples were collected from various poultry farms in …