The enteric nervous system (ENS) is a rich network of neurons and glial cells that comprise
the gastrointestinal tract's intrinsic nervous system and are responsible for controlling …

The gastrointestinal (GI) tract is innervated by intrinsic enteric neurons and by extrinsic
efferent and afferent nerves. The enteric (intrinsic) nervous system (ENS) in most regions of …

Background & Aims Hirschsprung disease (HSCR) is a life-threatening birth defect in which
the distal colon is devoid of enteric neural ganglia. HSCR is treated by surgical removal of …

Over the last 20 years, there has been increasing focus on the development of novel stem
cell based therapies for the treatment of disorders and diseases affecting the enteric nervous …

Cell therapy offers the potential to replace the missing enteric nervous system (ENS) in
patients with Hirschsprung disease (HSCR) and to restore gut function. The Schwann cell …

Acquired or congenital disruption in enteric nervous system (ENS) development or function
can lead to significant mechanical dysmotility. ENS restoration through cellular …

Paper 2 of the paediatric regenerative medicine Series focuses on recent advances in
postnatal approaches. New gene, cell, and niche-based technologies and their …

Neurocristopathies form a heterogeneous group of rare diseases caused by abnormal
development of neural crest cells. Heterogeneity of neurocristopathies directly relates to the …

Despite significant progress in our understanding of the etiology and pathophysiology of
Hirschsprung disease (HSCR), early and accurate diagnosis and operative management …

Background: Enteric neural stem/progenitor cells (ENSCs) offer an innovative approach to
treating Hirschsprung disease (HSCR) and other enteric neuropathies. However, postnatal …