Background The discovery of nutritious dietary supplements and side effect-free
therapeutics are a priority in the current scenario of increasing cancer cases. Natural …

Background Cuproptosis is a newly discovered unique non-apoptotic programmed cell
death distinguished from known death mechanisms like ferroptosis, pyroptosis, and …

Ferroptosis is a cell death process driven by damage to cell membranes and linked to
numerous human diseases. Ferroptosis is caused by loss of activity of the key enzyme that is …

Hypoxia occurs naturally at high-altitudes and pathologically in hypoxic solid tumors. Here,
we report that genes involved in various human cancers evolved rapidly in Tibetans and six …

Concurrent loss-of-function mutations in STK11 and KEAP1 in lung adenocarcinoma
(LUAD) are associated with aggressive tumor growth, resistance to available therapies, and …

High-order chromatin organization plays an important role in biological processes and
disease development. Previous studies revealed a widespread occurrence of guanine …

The fine-tuning of the physicochemical properties of gold nanoparticles has facilitated the
rapid development of multifunctional gold-based nanomaterials with diagnostic, therapeutic …

Anthranilic acid and its analogues present a privileged profile as pharmacophores for the
rational development of pharmaceuticals deliberated for managing the pathophysiology and …

Human aldo-keto reductase family 1 member C3 (AKR1C3) is known as a hormone activity
regulator and prostaglandin F (PGF) synthase that regulates the occupancy of hormone …

Purpose: To evaluate the precise mode of cell death and to investigate the molecular
mechanism underlying the initiation of inflammation in dry eye disease (DED). Methods …