Is dysregulation of the HPA-axis a core pathophysiology mediating co-morbid depression in neurodegenerative diseases?
There is increasing evidence of prodromal manifestation of neuropsychiatric symptoms in a
variety of neurodegenerative diseases such as Parkinson's disease (PD) and Huntington's …
variety of neurodegenerative diseases such as Parkinson's disease (PD) and Huntington's …
Environmental factors as modulators of neurodegeneration: Insights from gene–environment interactions in Huntington's disease
Unlike many other neurodegenerative diseases with established gene–environment
interactions, Huntington's disease (HD) is viewed as a disorder governed by genetics. The …
interactions, Huntington's disease (HD) is viewed as a disorder governed by genetics. The …
Mice lacking GPR88 show motor deficit, improved spatial learning, and low anxiety reversed by delta opioid antagonist
Background GPR88 is an orphan G protein coupled receptor highly enriched in the striatum,
and previous studies have focused on GPR88 function in striatal physiology. The receptor is …
and previous studies have focused on GPR88 function in striatal physiology. The receptor is …
[HTML][HTML] Environmental stimulation in Huntington disease patients and animal models
A Novati, HP Nguyen, J Schulze-Hentrich - Neurobiology of Disease, 2022 - Elsevier
While Huntington disease (HD) is caused solely by a polyglutamine expansion in the
huntingtin gene, environmental factors can influence HD onset and progression. Here, we …
huntingtin gene, environmental factors can influence HD onset and progression. Here, we …
What's wrong with my mouse cage? Methodological considerations for modeling lifestyle factors and gene–environment interactions in mice
The mechanistic understanding of lifestyle contributions to disease has been largely driven
by work in laboratory rodent models using environmental interventions. These interventions …
by work in laboratory rodent models using environmental interventions. These interventions …
[HTML][HTML] Normalizing glucocorticoid levels attenuates metabolic and neuropathological symptoms in the R6/2 mouse model of huntington's disease
BD Dufour, JL McBride - Neurobiology of disease, 2019 - Elsevier
Huntington's disease (HD) is a fatal genetic neurological disorder caused by a mutation in
the human Huntingtin (HTT) gene. This mutation confers a toxic gain of function of the …
the human Huntingtin (HTT) gene. This mutation confers a toxic gain of function of the …
[PDF][PDF] Normalizing glucocorticoid levels attenuates metabolic and neuropathological symptoms in the R6/2 mouse model of huntington's
BD Dufoura, JL McBridea - Neurobiology of Disease, 2019 - academia.edu
Huntington's disease (HD) is a fatal genetic neurological disorder caused by a mutation in
the human Huntingtin (HTT) gene. This mutation confers a toxic gain of function of the …
the human Huntingtin (HTT) gene. This mutation confers a toxic gain of function of the …
The effects of environmental and microbiota manipulation on myelination in the YAC128 and BACHD models of Huntington disease
CI Radulescu - 2017 - etheses.whiterose.ac.uk
White matter (WM) deterioration is increasingly being recognised as a hallmark of
Huntington disease (HD) and is correlated to disease severity. The research presented in …
Huntington disease (HD) and is correlated to disease severity. The research presented in …