A review on synthetic strategy, molecular pharmacology of indazole derivatives, and their future perspective

S Mal, U Malik, M Mahapatra, A Mishra… - Drug Development …, 2022 - Wiley Online Library
With different nitrogen‐containing heterocyclic moieties, Indazoles earn one of the places
among the top investigated molecules in medicinal research. Indazole, an important fused …

Complexification of in vitro models of intestinal barriers, a true challenge for a more accurate alternative approach

MJ Haddad, W Sztupecki, C Delayre-Orthez… - International journal of …, 2023 - mdpi.com
The use of cell models is common to mimic cellular and molecular events in interaction with
their environment. In the case of the gut, the existing models are of particular interest to …

Synthesis and biological evaluation of benzofuran piperazine derivatives as potential anticancer agents

TJ Schumacher, N Sah, K Palle, J Rumbley… - Bioorganic & Medicinal …, 2023 - Elsevier
This work describes about the synthesis and evaluation of substituted benzofuran
piperazines as potential anticancer agents. The synthesized candidates have been …

Diarylureas as antitumor agents

A Catalano, D Iacopetta, MS Sinicropi, C Franchini - Applied Sciences, 2021 - mdpi.com
The diarylurea is a scaffold of great importance in medicinal chemistry as it is present in
numerous heterocyclic compounds with antithrombotic, antimalarial, antibacterial, and anti …

[HTML][HTML] Synthesis, in vitro, and in silico study of novel pyridine based 1, 3-diphenylurea derivatives as tyrosinase inhibitors

AR Pasha, M Khan, A Khan, J Hussain… - Bioorganic …, 2024 - Elsevier
Tyrosinase inhibitors are studied in the cosmetics and pharmaceutical sectors as tyrosinase
enzyme is involved in the biosynthesis and regulation of melanin, hence these inhibitors are …

Molecular mechanisms of canine osteosarcoma metastasis

SS Wilk, KA Zabielska-Koczywąs - International journal of molecular …, 2021 - mdpi.com
Osteosarcoma (OSA) represents the most common bone tumor in dogs. The malignancy is
highly aggressive, and most of the dogs die due to metastasis, especially to the lungs. The …

Imatinib mesylate-loaded rosin/cinnamon oil-based in situ forming gel against colorectal cancer cells

EM Khaing, T Intaraphairot, J Mahadlek, S Okonogi… - Gels, 2022 - mdpi.com
Localized delivery systems have been typically designed to enhance drug concentration at a
target site and minimize systemic drug toxicity. A rosin/cinnamon oil (CO) in situ forming gel …

Palladium-Catalyzed Carbonylation of Amines with Mo(CO)6 as the Carbonyl Source

B Zhang, W Deng, ZY Xu - Organometallics, 2023 - ACS Publications
Catalytic carbonylation of transition metals is widely used as an effective means to
synthesize carbonyl-containing compounds. In this article, we introduce a method for the …

Synthesis and biological evaluation of indazole derivatives as anti-cancer agents

W Wei, Z Liu, X Wu, C Gan, X Su, H Liu, H Que… - RSC …, 2021 - pubs.rsc.org
Several FDA approved small molecule anti-cancer drugs contain indazole scaffolds. Here,
we report the design, synthesis and biological evaluation of a series of indazole derivatives …

Indazole derivatives as selective inhibitors of butyrylcholinesterase with effective blood-brain-barrier permeability profile

AJ Tobuse, CSW Law, CK Thy, JJ James… - Medicinal Chemistry …, 2024 - Springer
Alzheimer's disease (AD) is a chronic disease that is multifactorial. Its underlying cause and
mechanisms are yet to be fully understood and numerous research are underway to develop …