Bioorthogonal chemistry represents a class of high-yielding chemical reactions that proceed
rapidly and selectively in biological environments without side reactions towards …

Traditionally, organic chemical reactions require organic solvents, toxic catalysts, heat, or
high pressure. However, copper‐free click chemistry has been shown to have favorable …

Bioorthogonal chemistries enable researchers to interrogate biomolecules in living systems.
These reactions are highly selective and biocompatible, and can be performed in many …

A nearly forgotten reaction discovered more than 60 years ago—the cycloaddition of a cyclic
alkyne and an organic azide, leading to an aromatic triazole—enjoys a remarkable …

Bioorthogonal reactions are chemical reactions that neither interact with nor interfere with a
biological system. The participating functional groups must be inert to biological moieties …

The surging development of bioorthogonal chemistry has profoundly transformed chemical
biology over the last two decades. Involving chemical partners that specifically react together …

The 1, 3-dipolar cycloaddition of azides with ring-strained alkynes is one of the few
bioorthogonal reactions suitable for specific biomolecule labeling in complex biological …

Systematically dissecting the molecular basis of the cell surface as well as its related
biological activities is considered as one of the most cutting-edge fields in fundamental …

Clicking 1,2,4,5-tetrazine and cyclooctynes with tunable reaction rates - Chemical
Communications (RSC Publishing) DOI:10.1039/C2CC16716F Royal Society of Chemistry …

This review provides a literature overview of bioorthogonal ligation methods for protein
modification, which have largely evolved over the last 15 years. Since 1990, various new …