The aldol reaction is one of the most important carbon–carbon bond formations in synthetic
organic chemistry. An enantioselective aldol reaction should provide an enantioenriched …

Disubstituted oxindoles with a stereogenic quaternary carbon center exist widely in various
natural products and biologically active compounds. Various strategies have been …

Oxindole scaffolds are prevalent in natural products and have been recognized as
privileged substructures in new drug discovery. Several oxindole-containing compounds …

A chitosan aerogel catalyzed asymmetric aldol reaction of ketones with isatins in the
presence of water is described. This protocol was found to be environmentally benign …

Optically active 2-azanorbornane-based organocatalysts were designed and synthesized,
and the catalytic activity of these catalysts in enantioselective aldol reactions of isatins with …

A highly diastereo-and enantioselective aldol reaction of isatins with silyl ketene imines was
realized by using a chiral N, N′-dioxide/GdIII complex (1 mol%), and with the addition of …

Enantioselective aldol reactions of various isatins with ketones using newly designed amino
amide organocatalysts were found to provide chiral 3‐substituted 3‐hydroxy‐2‐oxindoles in …

A highly enantioselective Mukaiyama aldol reaction of silyl enol ethers with isatins catalyzed
by chiral copper complexes was developed. A series of chiral 3-substituted 3-hydroxy-2 …

Introduction: The popularity of chitosan is increasing among the researchers due to its
environment friendly nature, high activity and easy approachability. Chitosan based …

Novel organocatalysts derived from (R)-and (S)-proline and incorporating a chiral
phosphoramide fragment were rationally designed and subsequently synthesized. These …