Chronic Lymphocytic Leukemia Treatment of CLL, the most common leukemia in the West,
has undergone a revolution in the past few years with the development of agents that target …

Bruton tyrosine kinase (BTK) is a nonreceptor tyrosine kinase that plays a central role in the
signal transduction of the B-cell antigen receptor and other cell surface receptors, both in …

Bruton´ s tyrosine kinase (BTK) inhibitor (BTKi) s block the B-cell receptor (BCR) signaling
cascade by binding to the BTK enzyme preventing the proliferation and survival of malignant …

The use of Bruton tyrosine kinase (BTK) inhibitors to block B-cell receptor (BCR)–dependent
NF-κB activation in lymphoid malignancies has been a major clinical advance, yet acquired …

Higher risks of infection are associated with some targeted drugs used to treat solid organ
and hematological malignancies, and an individual patient's risk of infection is strongly …

Cryptococcosis caused by the Cryptococcus neoformans–Cryptococcus gattii complex is an
important opportunistic infection in people with immunodeficiency, including in the …

The continuous expansion of immunocompromised patient populations at-risk for
developing life-threatening opportunistic fungal infections in recent decades has helped …

Patients with hematologic malignancies and hematopoietic cell transplant recipients (HCT)
are at high risk for invasive fungal disease (IFD). The practice of antifungal prophylaxis with …

1 BTK inhibitor-induced defects in human neutrophil effector activity against Aspergillus 1
fumigatus are restored by TNFα 2 3 Page 1 1 BTK inhibitor-induced defects in human …

CLL is associated with an increased risk of infectious complications. Treatment with BTK or
BCL-2 inhibitors does not seem to increase significantly the risk of opportunistic infections …