Dysmaturation of premature brain: importance, cellular mechanisms, and potential interventions

JJ Volpe - Pediatric neurology, 2019 - Elsevier
Prematurity, especially preterm birth (less than 32 weeks' gestation), is common and
associated with high rates of both survival and neurodevelopmental disability, especially …

Early environment and long-term outcomes of preterm infants

JLY Cheong, AC Burnett, K Treyvaud… - Journal of Neural …, 2020 - Springer
Prematurity is associated with an increased risk of long-term health and
neurodevelopmental problems. Key perinatal and neonatal factors that affect these …

Bumetanide for the treatment of seizures in newborn babies with hypoxic ischaemic encephalopathy (NEMO): an open-label, dose finding, and feasibility phase 1/2 …

RM Pressler, GB Boylan, N Marlow, M Blennow… - The Lancet …, 2015 - thelancet.com
Background Preclinical data suggest that the loop-diuretic bumetanide might be an effective
treatment for neonatal seizures. We aimed to assess dose and feasibility of intravenous …

Newborn and infant hearing screening facing globally growing numbers of people suffering from disabling hearing loss

K Neumann, S Chadha, G Tavartkiladze, X Bu… - International Journal of …, 2019 - mdpi.com
Recent prevalence estimates indicate that in 2015 almost half a billion people—about 6.8%
of the world's population—had disabling hearing loss and that prevalence numbers will …

[HTML][HTML] A proposal for comprehensive newborn hearing screening to improve identification of deaf and hard-of-hearing children

AE Shearer, J Shen, S Amr, CC Morton, RJ Smith - Genetics in Medicine, 2019 - Elsevier
Early intervention for newborns who are deaf or hard-of-hearing leads to improved
language, communication, and social–emotional outcomes. Universal physiologic newborn …

[HTML][HTML] The fetal inflammatory response syndrome: the origins of a concept, pathophysiology, diagnosis, and obstetrical implications

E Jung, R Romero, L Yeo, R Diaz-Primera… - Seminars in Fetal and …, 2020 - Elsevier
The fetus can deploy a local or systemic inflammatory response when exposed to
microorganisms or, alternatively, to non-infection-related stimuli (eg, danger signals or …

Biological and social influences on the neurodevelopmental outcomes of preterm infants

AC Burnett, JLY Cheong… - Clinics in …, 2018 - perinatology.theclinics.com
Biological influences are important markers of later motor, vision, and hearing impairments,
although the mechanisms behind these outcomes remain incompletely understood …

Towards the prevention of aminoglycoside-related hearing loss

ME O'Sullivan, A Perez, R Lin, A Sajjadi… - Frontiers in cellular …, 2017 - frontiersin.org
Aminoglycosides are potent antibiotics deployed worldwide despite their known side-effect
of sensorineural hearing loss. The main etiology of this sensory deficit is death of inner ear …

Pre-treatment with fasudil prevents neomycin-induced hair cell damage by reducing the accumulation of reactive oxygen species

Y Zhang, W Li, Z He, Y Wang, B Shao… - Frontiers in Molecular …, 2019 - frontiersin.org
Ototoxic drug-induced hair cell (HC) damage is one of the main causes of sensorineural
hearing loss, which is one of the most common sensory disorders in humans …

Blebbistatin inhibits neomycin-induced apoptosis in hair cell-like HEI-OC-1 cells and in cochlear hair cells

S Gao, C Cheng, M Wang, P Jiang, L Zhang… - Frontiers in Cellular …, 2020 - frontiersin.org
Aging, noise, and ototoxic drug-induced hair cell (HC) loss are the major causes of
sensorineural hearing loss. Aminoglycoside antibiotics are commonly used in the clinic, but …