Antinuclear autoantibodies in health: autoimmunity is not a synonym of autoimmune disease

IA Pashnina, IM Krivolapova, TV Fedotkina… - Antibodies, 2021 - mdpi.com
The incidence of autoimmune diseases is increasing. Antinuclear antibody (ANA) testing is a
critical tool for their diagnosis. However, ANA prevalence in healthy persons has increased …

Anti-DFS70 Antibodies for differentiating systemic autoimmune rheumatic disease in patients with positive ANA tests: a systematic review and meta-analysis

CF Cheng, MC Shih, TY Lan, KJ Li - Diagnostics, 2021 - mdpi.com
Anti-DFS70 antibodies have been proposed as a marker to exclude systemic autoimmune
rheumatic disease (SARD). We conducted this systematic diagnostic test accuracy review …

The antinuclear antibody dense fine speckled pattern and possible clinical associations: An indication of a proinflammatory microenvironment

MC Lundgren, S Sapkota, DJ Peterson… - Journal of Immunological …, 2021 - Elsevier
Background Indirect immunofluorescence (IIF) is the most prevalent screening antinuclear
antibody test for systemic autoimmune rheumatic disease (SARD). Certain IIF patterns have …

Anti‐DFS70 antibodies are associated with atopic dermatitis and can cause misdiagnosis of connective tissue disease

B Santler, L Wimmer, B Schlueter… - JDDG: Journal der …, 2023 - Wiley Online Library
Summary Background and Objectives Antinuclear antibodies (ANA) detected by HEp2 cell
immunofluorescence staining are a characteristic finding in patients with connective tissue …

The Role of Anti-DFS70 in the Diagnosis of Systemic Autoimmune Rheumatic Diseases

L Zotova, V Kotova, Z Kuznetsov - Biologics, 2023 - mdpi.com
The diagnosis of systemic autoimmune rheumatic disease (SARD) or its exclusion is carried
out taking into account the results of immunological studies, primarily antinuclear antibodies …

Low prevalence of anti-DFS70 antibodies in children with ANA-associated autoimmune disease

M Freudenhammer, U Salzer, A Heselich… - Frontiers in …, 2022 - frontiersin.org
Introduction Anti-DFS70 antibodies occur in healthy individuals with various medical
conditions. Unlike other anti-nuclear autoantibodies (ANA), they are not associated with …

Monospecific anti-DFS70 antibodies are moderately helpful in excluding ANA-associated rheumatic disease in patients presenting with a dense fine speckled pattern …

CF Cheng, TY Lan, MC Shih… - Autoimmunity reviews, 2020 - pubmed.ncbi.nlm.nih.gov
Monospecific anti-DFS70 antibodies are moderately helpful in excluding ANA-associated
rheumatic disease in patients presenting with a dense fine speckled pattern - A systematic …

Antinuclear antibodies in follicular fluid may be a risk factor in vitro fertilization and embryo transfer

S Wu, L Zhang, X Liu, Y Jiang… - American Journal of …, 2022 - Wiley Online Library
Objective To explore the effect of anti‐nuclear antibodies (ANAs) on the outcome of in vitro
fertilization‐embryo transplantation (IVF‐ET) and to study the effect of ANAs in follicular fluid …

DFS70 Autoantibodies: Clinical Utility in Antinuclear Antibody Testing

X Bossuyt - Clinical Chemistry, 2024 - academic.oup.com
Background Screening for antinuclear antibodies (ANA) by indirect immunofluorescence
(IIF) on HEp-2 cells is helpful for the diagnosis and classification of ANA-associated …

Improved performance of confirmatory assays for detecting dense fine speckled (DFS) 70 antibodies

X Wei, R Chen, C Yang, K Nguyen, D Wakefield - Pathology, 2022 - Elsevier
The presence of monospecific dense fine speckled 70 (DFS70) pattern in indirect
immunofluorescence assay (IFA) without concomitant systemic autoimmune related …