Phosphoinositides (PIs) make up only a small fraction of cellular phospholipids, yet they
control almost all aspects of a cell's life and death. These lipids gained tremendous research …

In electrically nonexcitable cells, Ca2+ influx is essential for regulating a host of kinetically
distinct processes involving exocytosis, enzyme control, gene regulation, cell growth and …

A proper dialogue between spermatozoa and the egg is essential for conception of a new
individual in sexually reproducing animals. Ca2+ is crucial in orchestrating this unique event …

Phosphoinositide-specific phospholipase C is an effector molecule in the signal transduction
process. It generates two second messengers, inositol-1, 4, 5-trisphosphate and …

Abstract Inositol 1, 4, 5‐trisphosphate (IP3) is a second messenger that induces the release
of Ca2+ from the endoplasmic reticulum (ER). The IP3 receptor (IP3R) was discovered as a …

Intracellular Ca 2+ stores play a central role in the regulation of cellular [Ca 2+] i and the
generation of complex [Ca 2+] signals such as oscillations and waves. Ca 2+ signalling is of …

The physiological effects of many extracellular neurotransmitters, hormones, growth factors,
and other stimuli are mediated by receptor-promoted activation of phospholipase C (PLC) …

Calcium and Ca 2+-dependent signals play a crucial role in sperm motility and mammalian
fertilization, but the molecules and mechanisms underlying these Ca 2+-dependent …

Thanks to a worrying decrease in male fertility, understanding how sperm'work'is a matter
both of interest and great importance. Sperm of all animals detect various environmental …

Spatial and temporal activation of phosphoinositide turnover enables eukaryotic cells to
perform various functions such as cell proliferation/differentiation, fertilization, neuronal …