The ability to adapt to changing internal and external conditions is a key feature of biological
systems. Homeostasis refers to a regulatory process that stabilizes dynamic systems to …

In the fruit fly, Drosophila melanogaster, the larval somatic muscles or the adult thoracic flight
and leg muscles are the major voluntary locomotory organs. They share several …

Anatomical and physiological compartmentalization of neurons is a mechanism to increase
the computational capacity of a circuit, and a major question is what role axonal …

Cytoplasmic protein tyrosine phosphatase nonreceptor type 11 (PTPN11) and Drosophila
homolog Corkscrew (Csw) regulate the mitogen-activated protein kinase (MAPK) pathway …

Synaptic heterogeneity is a hallmark of complex nervous systems that enables reliable and
responsive communication in neural circuits. In this study, we investigated the contributions …

Evidence suggests that impaired synaptic and firing homeostasis represents a driving force
of early Alzheimer's disease (AD) progression. Here, we examine synaptic and sleep …

To identify conserved components of synapse function that are also associated with human
diseases, we conducted a genetic screen. We used the Drosophila melanogaster …

Neuropeptides control rhythmic behaviors, but the timing and location of their release within
circuits is unknown. Here, imaging in the brain shows that synaptic neuropeptide release by …

Synaptic heterogeneity is a hallmark of nervous systems that enables complex and
adaptable communication in neural circuits. To understand circuit function, it is thus critical to …

Synaptic heterogeneity is a hallmark of nervous systems that enables complex and
adaptable communication in neural circuits. To understand circuit function, it is thus critical to …