Abstract The Steroidogenic Acute R egulatory Protein-related Lipid T ransfer (START)
domain is a~ 210 amino acid sequence that folds into an α/β helix-grip structure forming a …

Simple Summary Alterations in cholesterol level play an important role in cancer
development. Lipid transfer proteins (LTPs) are involved in cholesterol distribution between …

Chromosome alignment to the spindle equator is a hallmark of mitosis thought to promote
chromosome segregation fidelity in metazoans. Yet chromosome alignment is only indirectly …

The mechanisms underlying the osteogenic differentiation of human bone marrow
mesenchymal stem cells (hBMSCs) remain unclear. In the present study, we aimed to …

Platelet-producing megakaryocytes (MKs) primarily reside in the bone marrow, where they
duplicate their DNA content with each cell cycle resulting in polyploid cells with an intricate …

Salicylate, the active derivative of aspirin (acetylsalicylate), recapitulates the mode of action
of caloric restriction inasmuch as it stimulates autophagy through the inhibition of the …

Background: To reveal candidate genes and the molecular genetic mechanism underlying
primary feather color trait in ducks, a genome-wide association study (GWAS) for the primary …

Genetic variations in ephrin type-A receptor 2 (EPHA2) have been associated with inherited
and age-related forms of cataract in humans. Here, we have characterized the eye lens …

Background Lung cancer is the leading cause of cancer-related deaths worldwide, with lung
adenocarcinoma (LAC) representing the most common subtype. Trophinin-associated …

Background Thermal stress in subtropical regions is a major limiting factor in beef cattle
production systems with around $369 million being lost annually due to reduced …