Dopamine, immunity, and disease

B Channer, SM Matt, EA Nickoloff-Bybel, V Pappa… - Pharmacological …, 2023 - Elsevier
The neurotransmitter dopamine is a key factor in central nervous system (CNS) function,
regulating many processes including reward, movement, and cognition. Dopamine also …

Dopaminergic impact of cART and anti-depressants on HIV neuropathogenesis in older adults

SM Matt, PJ Gaskill - Brain research, 2019 - Elsevier
The success of combination antiretroviral therapy (cART) has transformed HIV infection into
a chronic condition, resulting in an increase in the number of older, cART-treated adults …

Combination antiretroviral therapy improves cognitive performance and functional connectivity in treatment-naïve HIV-infected individuals

Y Zhuang, X Qiu, L Wang, Q Ma, M Mapstone… - Journal of …, 2017 - Springer
Our study aimed to investigate the short-term effect of combination antiretroviral therapy
(cART) on cognitive performance and functional and structural connectivity and their …

[HTML][HTML] Chronic HIV-1 Tat exposure alters anterior cingulate cortico-basal ganglia-thalamocortical synaptic circuitry, associated behavioral control, and immune …

SR Nass, YK Hahn, VD McLane, NB Varshneya… - Brain, behavior, & …, 2020 - Elsevier
HIV-1 selectively disrupts neuronal integrity within specific brain regions, reflecting
differences in viral tropism and/or the regional differences in the vulnerability of distinct …

Human immunodeficiency virus‐related decreases in corpus callosal integrity and corresponding increases in functional connectivity

SA Hall, RP Bell, SW Davis, SL Towe… - Human brain …, 2021 - Wiley Online Library
People living with human immunodeficiency virus (PLWH) often have neurocognitive
impairment. However, findings on HIV‐related differences in brain network function …

[HTML][HTML] Medial prefrontal cortex connectivity with the nucleus accumbens is related to HIV serostatus, perceptions of psychological stress, and monocyte expression of …

R McIntosh, J Lobo, A Szeto, M Hidalgo… - Brain, Behavior, & …, 2024 - Elsevier
Post-menopausal persons living with HIV (PWH) report elevated levels of psychological
stress and monocyte activation compared to persons living without HIV (PWOH). Resting …

Comparison of resting state functional connectivity in persons with and without HIV: a cross-sectional study

S Thippabhotla, B Adeyemo, SA Cooley… - The Journal of …, 2023 - academic.oup.com
Background This study examined the effects of human immunodeficiency virus (HIV) on
resting state functional connectivity (RSFC) in a large cohort of people with HIV (PWH) and …

White matter of perinatally HIV infected older youths shows low frequency fluctuations that may reflect glial cycling

MK Sarma, A Pal, MA Keller, T Welikson, J Ventura… - Scientific reports, 2021 - nature.com
In perinatally HIV-infected (PHIV) children, neurodevelopment occurs in the presence of HIV-
infection, and even with combination antiretroviral therapy (cART) the brain can be a …

Diagnostic and prognostic biomarkers for HAND

KA McLaurin, RM Booze, CF Mactutus - Journal of neurovirology, 2019 - Springer
In 2007, the nosology for HIV-1-associated neurocognitive disorders (HAND) was updated
to a primarily neurocognitive disorder. However, currently available diagnostic tools lack the …

Effects of early HIV infection and combination antiretroviral therapy on intrinsic brain activity: a cross-sectional resting-state fMRI study

R Li, W Wang, Y Wang, S Peters… - … Disease and Treatment, 2019 - Taylor & Francis
Objective: To investigate effects of early HIV infection and combination antiretroviral therapy
(cART) on intrinsic brain activity by using amplitude of low-frequency fluctuation (ALFF) …