Major depressive disorder (MDD) is underlined by neurochemical changes in the brain.
Proton magnetic resonance spectroscopy (1 H MRS) is a useful tool for their examination as …

Numerous studies have investigated metabolite alterations resulting from pharmacological
treatment in depression models although few quantitative studies explored metabolites …

Magnetic resonance imaging (MRI) is a valuable translational tool that can be used to
investigate alterations in brain structure and function in both patients and animal models of …

Depression is a complex psychiatric disorder characterized by anhedonia and feeling of
sadness and chronic mild stress (CMS) seems to be a valuable animal model of depression …

Major depressive disorder (MDD) is a debilitating mood disorder with various
etiopathological hypotheses. However the pathogenesis and diagnosis are still unclear …

Our previous studies found that n-3 polyunsaturated fatty acids (PUFAs) and estrogen had
synergistic antidepressant-like effects. The purpose of the present study was to investigate …

Hypothalamic dysfunction is a key factor in depression; increasing evidence highlights
neuroinflammation abnormalities as well as imbalances in neurotransmitters and the …

Fluoxetine (Flx)-induced neuronal plasticity plays an important role in the effective treatment
of depression and mood disorders. It is less understood whether repeated Flx treatment …

Objective Social defeat represents a naturalistic form of conditioned fear and is often used
as an animal model of depression. The present study aimed to identify the neurochemicals …

Background Depression is a common comorbid psychiatric symptom in patients with
Alzheimer's disease (AD), and the prevalence of depression is higher among people with …