The stringent response is a stress signalling system mediated by the alarmones guanosine
tetraphosphate (ppGpp) and guanosine pentaphosphate (pppGpp) in response to nutrient …

Clinical management of Staphylococcus aureus infections presents a challenge due to the
high incidence, considerable virulence, and emergence of drug resistance mechanisms …

Initiation of DNA replication in Escherichia coli is coupled to cell size via the DnaA protein,
whose activity is dependent on its nucleotide-bound state. However, the oscillations in DnaA …

Two (p) ppGpp nucleotide analogs, sometimes abbreviated simply as ppGpp, are
widespread in bacteria and plants. Their name alarmone reflects a view of their function as …

Despite a boost of recent progress in dynamic single-cell measurements and analyses in
Escherichia coli, we still lack a mechanistic understanding of the determinants of the …

Heterotrophic Proteobacteria are versatile opportunists that have been extensively studied
as model organisms in the laboratory, as both pathogens and beneficial symbionts of plants …

Growth and division are central to cell size. Bacteria achieve size homeostasis by dividing
when growth has added a constant size since birth, termed the adder principle, by unknown …

The signaling nucleotide (p) ppGpp has been the subject of intense research in the past two
decades. Initially discovered as the effector molecule of the stringent response, a bacterial …

The DnaA protein has long been considered to play the key role in the initiation of
chromosome replication in modern bacteria. Many questions about this role, however …

Despite abundant measurements of bacterial growth rate, cell size, and protein content, we
lack a rigorous understanding of what sets the scale of these quantities and when protein …