Alternative splicing is a widespread process contributing to structural transcript variation and
proteome diversity. In cancer, the splicing process is commonly disrupted, resulting in both …

Current efforts in precision oncology largely focus on the benefit of genomics-guided
therapy. Yet, advances in sequencing techniques provide an unprecedented view of the …

Synthetic lethality occurs when the inhibition of two genes is lethal while the inhibition of
each single gene is not. It can be harnessed to selectively treat cancer by identifying inactive …

While synthetic lethality (SL) holds promise in developing effective cancer therapies, SL
candidates found via experimental screens often have limited translational value. Here we …

Synthetic lethality (SL) is a type of genetic interaction between two genes such that
simultaneous perturbations of the two genes result in cell death or a dramatic decrease of …

We present an integrated approach that predicts and validates novel anti-cancer drug
targets. We first built a classifier that integrates a variety of genomic and systematic datasets …

Arc is an activity-regulated neuronal protein, but little is known about its interactions,
assembly into multiprotein complexes, and role in human disease and cognition. We applied …

Proteins are not monolithic entities; rather, they can contain multiple domains that mediate
distinct interactions, and their functionality can be regulated through post-translational …

A central challenge in evolutionary biology concerns the mechanisms by which complex
metabolic innovations requiring multiple mutations arise. Here, we propose that metabolic …

Motivation A synthetic lethal (SL) interaction is a relationship between two functional entities
where the loss of either one of the entities is viable but the loss of both entities is lethal to the …