A roadmap for the human developmental cell atlas
Abstract The Human Developmental Cell Atlas (HDCA) initiative, which is part of the Human
Cell Atlas, aims to create a comprehensive reference map of cells during development. This …
Cell Atlas, aims to create a comprehensive reference map of cells during development. This …
Neuronal cell-type classification: challenges, opportunities and the path forward
Neurons have diverse molecular, morphological, connectional and functional properties. We
believe that the only realistic way to manage this complexity—and thereby pave the way for …
believe that the only realistic way to manage this complexity—and thereby pave the way for …
Molecular architecture of the developing mouse brain
The mammalian brain develops through a complex interplay of spatial cues generated by
diffusible morphogens, cell–cell interactions and intrinsic genetic programs that result in …
diffusible morphogens, cell–cell interactions and intrinsic genetic programs that result in …
[HTML][HTML] Biphasic activation of WNT signaling facilitates the derivation of midbrain dopamine neurons from hESCs for translational use
Human pluripotent stem cells show considerable promise for applications in regenerative
medicine, including the development of cell replacement paradigms for the treatment of …
medicine, including the development of cell replacement paradigms for the treatment of …
Classification of midbrain dopamine neurons using single-cell gene expression profiling approaches
JF Poulin, Z Gaertner, OA Moreno-Ramos… - Trends in …, 2020 - cell.com
Dysfunctional dopamine (DA) signaling has been associated with a broad spectrum of
neuropsychiatric disorders, prompting investigations into how midbrain DA neuron …
neuropsychiatric disorders, prompting investigations into how midbrain DA neuron …
[HTML][HTML] Neural subtype specification from human pluripotent stem cells
Y Tao, SC Zhang - Cell stem cell, 2016 - cell.com
Human pluripotent stem cells (hPSCs) provide a model to study early neural development,
model pathological processes, and develop therapeutics. The generation of functionally …
model pathological processes, and develop therapeutics. The generation of functionally …
Predictive markers guide differentiation to improve graft outcome in clinical translation of hESC-based therapy for Parkinson's disease
Stem cell treatments for neurodegenerative diseases are expected to reach clinical trials
soon. Most of the approaches currently under development involve transplantation of …
soon. Most of the approaches currently under development involve transplantation of …
Generation of high-purity human ventral midbrain dopaminergic progenitors for in vitro maturation and intracerebral transplantation
Generation of precisely patterned neural cells from human pluripotent stem cells (hPSCs) is
instrumental in developing disease models and stem cell therapies. Here, we provide a …
instrumental in developing disease models and stem cell therapies. Here, we provide a …
Single-cell RNA sequencing reveals midbrain dopamine neuron diversity emerging during mouse brain development
Midbrain dopamine (mDA) neurons constitute a heterogenous group of cells that have been
intensely studied, not least because their degeneration causes major symptoms in …
intensely studied, not least because their degeneration causes major symptoms in …
[HTML][HTML] The BRAIN initiative cell census consortium: lessons learned toward generating a comprehensive brain cell atlas
A comprehensive characterization of neuronal cell types, their distributions, and patterns of
connectivity is critical for understanding the properties of neural circuits and how they …
connectivity is critical for understanding the properties of neural circuits and how they …