Hesperidin: A therapeutic agent for obesity

H Xiong, J Wang, Q Ran, G Lou, C Peng… - Drug design …, 2019 - Taylor & Francis
Obesity is a chronic metabolic disease caused by multiple factors and is considered to be a
risk factor for type 2 diabetes, cardiovascular disease, hypertension, stroke and various …

Anti-diabetic potentials of vernonioside e saponin; a biochemical study

DE Uti, GO Igile, WA Omang, GU Umoru… - … & ESSENTIAL OILS …, 2021 - nveo.org
Aim: Saponinshave been reported to demonstrate glucose lowering potentials in diabetic
conditions. This study was aimed at investigating the effect of Vernonioside E (VE), a …

Buchholzia coriacea Leaves Attenuated Dyslipidemia and Oxidative Stress in Hyperlipidemic Rats and Its Potential Targets In Silico

DE Uti, UA Ibiam, WA Omang, PA Udeozor… - Pharmaceutical …, 2023 - thieme-connect.com
The study aimed to investigate how the solvent extract of Buchholzia coriacea (BCE), a
widely known hypolipidemic agent, could contribute to hyperlipidemia treatment and identify …

Tetracarpidium conophorum nuts (African walnuts) up‐regulated adiponectin and PPAR‐γ expressions with reciprocal suppression of TNF‐α gene in obesity

GU Umoru, IJ Atangwho, E David‐Oku… - Journal of Cellular …, 2024 - Wiley Online Library
Tetracarpidium conophorum nuts are nutrient‐dense Nigerian snacks associated with
weight regulation. This study explores the nuts' impact on adipose tissue gene expression …

Chemical characterization, anti-nociceptive and anti-inflammatory activities of Plukenetia conophora seed oil in experimental rodent models

AM Ajayi, CB Ola, MB Ezeagu, PA Adeleke… - Journal of …, 2023 - Elsevier
Ethnopharmacological relevance The seed of the African walnut, Plukenetia conophora
Mull.-Arg is well-known for its nutritional and medicinal values. The seed oil is widely used in …

Cytokines as Key Players in Obesity Low Grade Inflammation and Related Complications

DE Uti, IJ Atangwho, WA Omang, EU Alum, UN Obeten… - Obesity Medicine, 2025 - Elsevier
Environmental factors, genetic factors, and metabolic factors all have a role in the
development of obesity, which is a complex worldwide health challenge. Furthermore, the …

Identification of some bioactive compounds from Trignonella foenumgraecum as possible inhibitors of PPARϒ for diabetes treatment through molecular docking …

OS Okoh, AH Yakubu, AE Adegboyega, DE Uti… - Plos one, 2023 - journals.plos.org
Oral antidiabetic agents including the peroxisome proliferator-activated receptor gamma
(PPARγ) agonists are available for the clinical management of diabetes mellitus (DM) but …

[HTML][HTML] African walnuts attenuate ectopic fat accumulation and associated peroxidation and oxidative stress in monosodium glutamate-obese Wistar rats

DE Uti, IJ Atangwho, EU Eyong, GU Umoru… - Biomedicine & …, 2020 - Elsevier
Aims African walnuts were previously shown to modulate hepatic lipid bio-accumulation in
obesity. Herein, we investigated the impact of the nuts on fat accumulation in adipose and …

The Therapeutic Role of Gastrodin in Combating Insulin Resistance, Inflammation, and Oxidative Stress Induced by Bisphenol-A

OU Orji, NJ Awoke, DE Uti, OD Obasi… - Natural Product …, 2024 - journals.sagepub.com
Objective Insulin resistance is a key feature of, type 2 diabetes mellitus (T2DM), and it has
been linked to an environmental pollutant bisphenol-A (BPA). Gastrodin, a derivative of …

Efficacy of using walnuts as statin adjuvants in hypertension management

PU Amadi, EN Agomuo, JA Amadi… - Clinical and …, 2022 - Taylor & Francis
Background Due to the widespread unorthodox use of nuts to improve cardiovascular
health, this clinical trial was carried out to evaluate the efficacy of walnut as an adjuvant …