As one of the well-known hallmarks of cancer malignancy, most proliferating cancer cells
exhibit enhanced rates of glycolysis. Hexokinase 2 (HK2) is the rate-limiting enzyme …

Cancer cells reprogram their metabolism to become" glycolysis-dominant," which enables
them to meet their energy and macromolecule needs and enhancing their rate of survival …

METTL3 is the catalytic subunit of the methyltransferase complex, which mediates m6A
modification to regulate gene expression. In addition, METTL3 regulates transcription in an …

Ovarian cancer is one of the most lethal cancers in female reproductive system due to
heterogeneity and lack of effective treatment. Targeting aerobic glycolysis, a predominant …

The main protease of SARS-CoV-2, 3-chymotrypsin-like protease (3CLpro), is a prominent
target for antiviral development due to its essential role in the viral life cycle. Research has …

Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) is responsible for
coronavirus disease 2019 (COVID‐19), one of the most challenging global pandemics of the …

Glycosylation is a critical post-translational modification (PTM) that affects the function of
proteins and regulates cell signaling, thereby regulating various biological processes …

Increased glycolysis is a key characteristic of malignant cells that contributes to their high
proliferation rates and ability to develop drug resistance. The glycolysis rate-limiting enzyme …

Hexokinases represent the gateway enzyme of glucose metabolism by regulating cellular
glucose uptake and glycolytic rate. Interestingly, some mammalian hexokinase isoforms …

Purpose Almonertinib, a third-generation EGFR-TKI, is becoming widely used in the clinic. In
recent years, glycolysis and cancer-associated fibroblasts (CAFs) have emerged as hotspots …