We have compiled 819 articles published in the year 2002 that involved commercial optical
biosensor technology. The literature demonstrates that the technology's application …

Phosphorylation is a ubiquitous post-translational modification in proteins, and the
phosphate group is present constitutively or transiently in most biological building blocks …

Peptides are important signaling modules, acting both as individual hormones and as parts
of larger molecules, mediating their protein-protein interactions. Many peptidic and …

Increasing evidence can be found that describing receptor ligand interactions in terms of a
''lock-and-key''model is no longer adequate. Receptors can be regarded as part of a …

Thermodynamic and kinetic studies of biomolecular interactions give insight into specificity
of molecular recognition processes and advance rational drug design. Binding of …

Surface plasmon resonance (SPR) is a powerful label-free diagnostic tool to study
biomolecular interactions. However, one of the drawbacks of SPR is the lack of controlled …

Spleen tyrosine kinase (Syk) plays an essential role in IgE receptor signaling (FcεRI), which
leads to mast cell degranulation. Divalent binding of the tandem SH2 domain (tSH2) of Syk …

Abstract The Syk tandem Src homology 2 domain (Syk tSH2) constitutes a flexible protein
module involved in the regulation of Syk kinase activity. The Syk tSH2 domain is assumed to …

The Syk protein plays an important role in immune receptor signaling. The Syk tandem SH2
domain (tSH2)–ITAM interaction is important for recruiting Syk to the receptor complex and …

We have investigated the interaction of peptides containing phosphohistidine analogues
and their homologues with the prototypical phosphotyrosine binding SH2 domain from the …