The E2F family of transcription factors (E2Fs) consist of eight genes in mammals. These
genes encode ten proteins that are usually classified as transcriptional activators or …

The transcription factor E2F1 plays a crucial role in mediating multiple cancer hallmark
capabilities that regulate cell cycle, survival, apoptosis, metabolism, and metastasis …

The liver contains a mixture of hepatocytes with diploid or polyploid (tetraploid, octaploid,
etc.) nuclear content. Polyploid hepatocytes are commonly found in adult mammals …

E2Fs are a family of pivotal transcription factors. Accumulative evidence indicates that
aberrant expression or activation of E2Fs is a common phenomenon in malignances, and …

Background Endometrial carcinoma (EC) is one of the most common gynecological
malignancies among women. Maternal embryonic leucine Zipper Kinase (MELK) is …

B-Myb is an important transcription factor that plays a critical role in gene expression
regulation and tumorigenesis. However, its functional implication in colorectal cancer …

Gastric cancer (GC) is the second most frequent cause of cancer-related mortality in the
world, with Eastern Asia having the highest incidence rates. E2F is a family of transcription …

Gastric cancer is the most common malignant tumor in the digestive tract, with very high
morbidity and mortality in developing countries. The pathogenesis of gastric cancer is a …

Hepatocellular carcinoma (HCC) is the sixth most common cancer worldwide and the third
leading cause of cancer-related death. Because of the fast growth, early hepatic metastasis …

Ovarian cancer (OC) is a gynecological malignancy with a poor prognosis and low survival
rate. E2F2 is a transcription activator that plays an indispensable role in cell proliferation and …