Neurodevelopmental disorders, like cancer, are connected to impaired chromatin remodelers, PI3K/mTOR, and PAK1-regulated MAPK
Neurodevelopmental disorders (NDDs) and cancer share proteins, pathways, and
mutations. Their clinical symptoms are different. However, individuals with NDDs have …
mutations. Their clinical symptoms are different. However, individuals with NDDs have …
Interneuron development and dysfunction
J Yang, X Yang, K Tang - The FEBS Journal, 2022 - Wiley Online Library
Understanding excitation and inhibition balance in the brain begins with the tale of two basic
types of neurons, glutamatergic projection neurons and GABAergic interneurons. The …
types of neurons, glutamatergic projection neurons and GABAergic interneurons. The …
16p11. 2 deletion is associated with hyperactivation of human iPSC-derived dopaminergic neuron networks and is rescued by RHOA inhibition in vitro
Reciprocal copy number variations (CNVs) of 16p11. 2 are associated with a wide spectrum
of neuropsychiatric and neurodevelopmental disorders. Here, we use human induced …
of neuropsychiatric and neurodevelopmental disorders. Here, we use human induced …
Deep learning predicts DNA methylation regulatory variants in the human brain and elucidates the genetics of psychiatric disorders
There is growing evidence for the role of DNA methylation (DNAm) quantitative trait loci
(mQTLs) in the genetics of complex traits, including psychiatric disorders. However, due to …
(mQTLs) in the genetics of complex traits, including psychiatric disorders. However, due to …
Genome-wide association study points to novel locus for gilles de la tourette syndrome
Background Tourette syndrome (TS) is a childhood-onset neurodevelopmental disorder of
complex genetic architecture and is characterized by multiple motor tics and at least one …
complex genetic architecture and is characterized by multiple motor tics and at least one …
Neural pathway for gut feelings: vagal interoceptive feedback from the gastrointestinal tract is a critical modulator of anxiety-like behavior
Background Anxiety disorders are associated with an altered perception of the body's
internal state. Therefore, understanding the neuronal basis of interoception can foster novel …
internal state. Therefore, understanding the neuronal basis of interoception can foster novel …
Structural and Functional Aspects of the Neurodevelopmental Gene NR2F1: From Animal Models to Human Pathology
C Tocco, M Bertacchi, M Studer - Frontiers in Molecular Neuroscience, 2021 - frontiersin.org
The assembly and maturation of the mammalian brain result from an intricate cascade of
highly coordinated developmental events, such as cell proliferation, migration, and …
highly coordinated developmental events, such as cell proliferation, migration, and …
Pathophysiological heterogeneity of the BBSOA neurodevelopmental syndrome
The formation and maturation of the human brain is regulated by highly coordinated
developmental events, such as neural cell proliferation, migration and differentiation. Any …
developmental events, such as neural cell proliferation, migration and differentiation. Any …
Neurodevelopmental disorders, immunity, and cancer are connected
R Nussinov, CJ Tsai, H Jang - Iscience, 2022 - cell.com
Immunity could be viewed as the common factor in neurodevelopmental disorders and
cancer. The immune and nervous systems coevolve as the embryo develops. Immunity can …
cancer. The immune and nervous systems coevolve as the embryo develops. Immunity can …
NAT10‐mediated ac4C modification promotes ectoderm differentiation of human embryonic stem cells via acetylating NR2F1 mRNA
J Ge, Z Wang, J Wu - Cell Proliferation, 2024 - Wiley Online Library
Cell fate determination in mammalian development is complex and precisely controlled and
accumulating evidence indicates that epigenetic mechanisms are crucially involved. N 4 …
accumulating evidence indicates that epigenetic mechanisms are crucially involved. N 4 …