The past years have established the importance of estrogens in the pathophysiology of
schizophrenia and have shown its relevance to clinical practice through its influence on …

Pre-clinical models, postmortem and neuroimaging studies all support a role for muscarinic
receptors in the molecular pathology of schizophrenia. From these data it was proposed that …

Abstract Background Catechol-O-methyltransferase (COMT) has been shown to influence
clinical pain, descending modulation, and exercise-induced symptom worsening. COMT …

The finding that the drug KarXT, a formulation of xanomeline and tropsium which targets
muscarinic receptors, has given a positive result in reducing the positive and negative …

Enzymatic methylation catalyzed by methyltransferases has a significant impact on many
human biochemical reactions. As the second most ubiquitous cofactor in humans, S …

Increased oxidative stress (OS) and depletion of nigrostriatal dopamine (DA) are closely
linked to the neurodegeneration observed in Parkinson's Disease (PD). Caffeic acid (CA) …

Postmortem and neuroimaging studies show low levels of cortical muscarinic M1 receptors
(CHRM1) in patients with schizophrenia which is significant because CHRM signalling has …

Having reported associations between catechol-O-methyltransferase (COMT) genotypes at
SNPs rs4818 and rs4680 with levels of soluble COMT (S-COMT) in human dorsolateral …

Methamphetamine use disorder (MAUD) can substantially jeopardize public security due to
its high‐risk social psychology and behaviour. Given that the dopamine reward system is …

It is suggested studying phenotypes within the syndrome of schizophrenia will accelerate
understanding the complex molecular pathology of the disorder. Supporting this hypothesis …