It is now well established that vascular inflammation is an independent risk factor for the
development of atherosclerosis. In otherwise healthy patients, chronic elevations of …

At present, diabetic kidney disease affects about 15–25% of type 1 and 30–40% of type 2
diabetic patients. Several decades of extensive research has elucidated various pathways to …

Diabetic nephropathy seems to occur as a result of an interaction of metabolic and
haemodynamic factors. Glucose dependent pathways are activated within the diabetic …

Activation of a local tissue angiotensin system in podocytes by mechanical strain.
Background Glomerular capillary hypertension, a common denominator in various forms of …

We tested the hypothesis that AMP-activated protein kinase (AMPK), an energy sensor,
regulates diabetes-induced renal hypertrophy. In kidney glomerular epithelial cells, high …

Optimal prevention and treatment of chronic kidney disease in diabetes requires
implementing therapies that specifically interfere with the pathogenesis of diabetic …

Background Diabetic nephropathy is the leading cause of kidney failure in the United States.
The extent to which an elevated glycated hemoglobin (HbA 1c) concentration is associated …

Diabetes mellitus and its complications are a public health problem. Diabetic nephropathy
has become the main cause of renal failure, and furthermore is associated with a dramatic …

Renin-angiotensin system activation and interstitial inflammation in human diabetic
nephropathy. Background The molecular mechanisms of renal injury in diabetic …

With aging, the kidney undergoes inexorable and progressive changes in structural and
functional performance. These aging‐related alterations are more obvious and serious in …