Cannabis sativa-derived compounds, such as delta-9-tetrahydrocannabinol (THC) and
cannabidiol (CBD), and components of the endocannabinoids system, such as N …

The psychoactive property of cannabinoids is well known and there has been a continuous
controversy regarding the usage of these compounds for therapeutic purposes all over the …

The number of people diagnosed with diabetes mellitus and its complications is markedly
increasing worldwide, leading to a worldwide epidemic across all age groups, from children …

Introduction: Cannabinoids such as▵-9-THC and CBD can downregulate the immune
response by modulating the endocannabinoid system. This modulation is relevant for the …

Toll-like receptors (TLRs) are sensors of pathogen-associated molecules that trigger
inflammatory signalling in innate immune cells including macrophages. All TLRs, with the …

Chronic musculoskeletal (MSK) pain is one of the most prevalent causes, which lead
patients to a physician's office. The most common disorders affecting MSK structures are …

In endotoxemic models, the inflammatory parameters are altered to a favorable direction as
a response to activation of cannabinoid receptors 1 and 2. The phytocannabinoid Δ9 …

Abstract Type-2 diabetes (T2D) increases the risk of dementia by˜ 5-fold, however the
mechanisms by which T2D increases dementia risk remain unclear. Evidence suggests that …

The innate immune response to bacterial and viral molecules involves the coordinated
production of cytokines, chemokines, and type I interferons (IFNs), which is orchestrated by …

Objectives A large amount of fructose is metabolized in the liver and causes hepatic
functional damage. Δ9-tetrahydrocannabinol (THC) is known as a therapeutic agent for …