Oligonucleotides (OGNs) are relatively new modalities that offer unique opportunities to
expand the therapeutic targets. Reliable and high-throughput bioanalytical methods are …

Therapeutic nucleic acids are various chemically modified RNA or DNA with different
functions, which mainly play roles at the gene level. Owing to its accurately targeting at …

Liquid chromatography-mass spectrometry has been widely implemented as a powerful tool
for providing in-depth characterization of nucleic acid therapeutic modalities, such as anti …

Improving our understanding of nucleic acids, both in biological and synthetic applications,
remains a bustling area of research for both academic and industrial laboratories. As nucleic …

As interest in oligonucleotide (ON) therapeutics is increasing, there is a need to develop
suitable analytical methods able to properly analyze those molecules. However, an issue …

With the development of therapeutic oligonucleotides for antisense and gene therapies, the
demand for analytical methods also increases. For the analysis of complex samples, for …

A small set of ribonucleoside modifications have been found in different regions of mRNA
including the open reading frame. Accurate detection of these specific modifications is …

Oligonucleotides (ONs) are gaining increasing importance as a promising novel class of
biopharmaceuticals. Thanks to their fundamental role in gene regulation, they can be used …

The development of new strategies for the analysis of nucleic acids has gained momentum
due to the increased interest in using these biomolecules as drugs or drug targets. The …

Ion-pairing reversed-phase liquid chromatography was utilized for the analysis of native and
phosphorothioate oligonucleotides of the identical sequence but different amount and …