Peptides constitute molecular diversity with unique molecular mechanisms of action that are
proven indispensable in the management of many human diseases, but of only a mere …

Recently developed strategies for late stage modification of peptides through Csingle bondH
activation, an arena of contemporary interest in chemical biology and drug discovery, are …

In recent years the model on which the pharmaceutical industry is based has undergone
dramatic changes. Every year, more biological entities are being accepted by the FDA and …

Here we describe several useful strategies to a variety of unusual α-amino acid derivatives
and peptides based on “building block” approach. These building blocks are suitable for …

The (site-selective) derivatization of amino acids and peptides represents an attractive field
with potential applications in the establishment of structure–activity relationships and …

We report a streamlined method for the synthesis of peptides embedded with complex and
easily variable π-conjugated oligomeric subunits from commercially available precursors …

An efficient arylation in water of tyrosine and phenylalanine side chains from unprotected
iodopeptides is accomplished by using Suzuki− Miyaura cross-coupling processes. The …

The functionalisation of peptides at a late synthesis stage holds great potential, for example,
for the synthesis of peptide pharmaceuticals, fluorescent biosensors or peptidomimetics …

Miyaura borylation and Suzuki–Miyaura cross-coupling have been combined to set up an
efficient strategy for the solid-phase synthesis of biaryl cyclic peptides. The Miyaura …

Abstract The Suzuki–Miyaura derivatisation of free amino acids, peptides and proteins is an
attractive area with considerable potential utility for medicinal chemistry and chemical …