Molecular Biology of Adenosine Triphosphate-Sensitive Potassium Channels* | Endocrine
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Hyperinsulinism in infancy is one of the most difficult problems to manage in contemporary
paediatric endocrinology. Although the diagnosis can usually be achieved without difficulty …

Background Macrosomia is associated with considerable neonatal and maternal morbidity.
Factors that predict macrosomia are poorly understood. The increased rate of macrosomia in …

Hyperinsulinism of infancy (HI), also known as persistent hyperinsulinemic hypoglycemia of
infancy, is a rare genetic disorder that occurs in approximately 1 of 50,000 live births …

Dunne, Mark J., Karen E. Cosgrove, Ruth M. Shepherd, Albert Aynsley-Green, and Keith J.
Lindley. Hyperinsulinism in Infancy: From Basic Science to Clinical Disease. Physiol Rev 84 …

The beta‐cell ATP‐sensitive potassium (KATP) channel is a key component of stimulus‐
secretion coupling in the pancreatic beta‐cell. The channel couples metabolism to …

Background The term congenital hyperinsulinism (CHI) comprises a group of different
genetic disorders with the common finding of recurrent episodes of hyperinsulinemic …

Hyperinsulinism is the single most common mechanism of hypoglycemia in neonates.
Dysregulated insulin secretion is responsible for the transient and prolonged forms of …

Background Neonatal hyperinsulinemic hypoglycemia is often resistant to medical therapy
and is often treated with near-total pancreatectomy. However, the pancreatic lesions may be …

Congenital hyperinsulinism (HI) is a clinically and genetically heterogeneous entity. The
clinical heterogeneity is manifested by severity ranging from extremely severe, life …